Evidence map›Paper›PMID 39823298›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Action potential-independent spontaneous microdomain Ca

Zhuoyu Zhang, Jingyu Yao, Jingxiao Huo, Ruolin Wang, Xueting Duan, Yang Chen, Huadong Xu, Changhe Wang, Zuying Chai, Rong Huang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. CaNeuroscience bulletin · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhuoyu Zhang *Department of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.ORCID 0000-0002-7427-2207
Jingyu Yao *Department of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.ORCID 0009-0007-0911-1363
Jingxiao Huo *Department of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.
Ruolin WangDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.
Xueting DuanDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.
Yang ChenDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.
Huadong XuDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.
Changhe WangDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.ORCID 0000-0002-5902-2277
Zuying ChaiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-1449-9351
Rong HuangDepartment of Neurology, the Second Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.ORCID 0000-0002-6901-5089

Funding

MOST | National Natural Science Foundation of China (NSFC) 32171233MOST | National Natural Science Foundation of China (NSFC) 32300819MOST | National Natural Science Foundation of China (NSFC) 82201404Natural Science Foundation of Shaanxi Province (Shaanxi Natural Science Foundation) 2024JC-YBMS-141Natural Science Foundation of Shaanxi Province (Shaanxi Natural Science Foundation) 2024JC-YBMS-146
6 · The paper itself

Abstract

Neurotransmitters and neuromodulators can be released via either action potential (AP)-evoked transient or AP-independent continuous neurotransmission. The elevated AP-evoked neurotransmission in the primary sensory neurons plays crucial roles in hyperalgesia. However, whether and how the AP-independent continuous neurotransmission contributes to hyperalgesia remains largely unknown. Here, we show that primary sensory dorsal root ganglion (DRG) neurons exhibit frequent spontaneous microdomain Ca

Indexed as

Action PotentialsCalciumHyperalgesiaSynaptic TransmissionAnimalsCyclic AMP-Dependent Protein KinasesGanglia, SpinalMaleMiceMice, Inbred C57BLSensory Receptor CellsTRPA1 Cation ChannelCalciumCyclic AMP-Dependent Protein KinasesTRPA1 Cation ChannelTrpa1 protein, mousecontinuous neurotransmissionhyperalgesiasensory dorsal root ganglion neuronsspontaneous microdomain Ca2+ activitiesTRPA1

Identifiers

PMID39823298
PMCPMC11759901

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.