Evidence map›Paper›PMID 39825147›Full record

ArticleJournal of muscle research and cell motility2025

The role of MEGF10 in myoblast fusion and hypertrophic response to overload of skeletal muscle.

Louise Richardson, Ruth Hughes, Colin A Johnson, Stuart Egginton, Michelle Peckham

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Louise Richardson *School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Ruth Hughes *School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Colin A JohnsonFaculty of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
Stuart EggintonSchool of Biomedical Science, University of Leeds, Leeds, LS2 9JT, UK.
Michelle Peckham *School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK. m.peckham@leeds.ac.uk.ORCID 0000-0002-3754-2028

Funding

Biotechnology and Biological Sciences Research Council BB/M011151/1Medical Research Council 1233630Medical Research Council MR/M000532/1Sir Jules Thorn Biomedical Award JTA/09
6 · The paper itself

Abstract

Biallelic mutations in multiple EGF domain protein 10 (MEGF10) gene cause EMARDD (early myopathy, areflexia, respiratory distress and dysphagia) in humans, a severe recessive myopathy, associated with reduced numbers of PAX7 positive satellite cells. To better understand the role of MEGF10 in satellite cells, we overexpressed human MEGF10 in mouse H-2k

Indexed as

Membrane ProteinsMuscle, SkeletalMyoblastsAnimalsCell DifferentiationCell FusionHumansHypertrophyMiceMice, TransgenicSatellite Cells, Skeletal MuscleMembrane ProteinsMEGF10MyogenesisOverload modelSatellite cellsSkeletal muscle

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.