Evidence map›Paper›PMID 39825470›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2025

Hypertensive disorders of pregnancy and gestational diabetes mellitus and predicted risk of maternal cardiovascular disease 10-14 years after delivery: A prospective cohort.

Kartik K Venkatesh, William A Grobman, Jiqiang Wu, Nilay S Shah, Michael Pencina, Maged M Costantine, Mark B Landon, Patrick Catalano, William L Lowe, Denise M Scholtens and 1 more

Abstract read
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kartik K VenkateshDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-8043-556X
William A GrobmanDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
Jiqiang WuDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
Nilay S ShahDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Michael PencinaDuke University, Durham, North Carolina, USA.
Maged M CostantineDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
Mark B LandonDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
Patrick CatalanoDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Tufts University, Boston, Massachusetts, USA.
William L LoweDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Denise M ScholtensDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sadiya S KhanDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Funding

PRegnancy OuTcomEs and subclinical Cardiovascular disease sTudy: (PROTECT)R01HL161514 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sadiya Sana Khan · 2022 to 2026
$3.3M
American Diabetes AssociationNational Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NHLBI NIH HHS HL161514NHLBI NIH HHS R01 HL161514NIH HHSThe Ohio State University
6 · The paper itself

Abstract

aimsStudies evaluating the relationship between adverse pregnancy outcomes (APOs), namely hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), with the estimated risk of atherosclerotic cardiovascular disease (ASCVD) remains limited and could inform patient-centred decision-making in the postpartum period. We examined whether HDP or GDM were associated with a higher 10- and 30-year predicted risk of ASCVD measured 10-14 years after delivery.

methodsA secondary analysis from the international prospective Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (2013-2016) cohort. The exposures were HDP or GDM (untreated according to the International Association of the Diabetes and Pregnancy Study Groups criteria). Outcomes were 10- and 30-year predicted risk of ASCVD (composite of fatal and non-fatal coronary heart disease and stroke) as quantified by the validated Framingham Risk Score as a continuous measure, and secondarily, at thresholds used for clinical decision-making of ≥7.5% for 10-year predicted risk and ≥20% for 30-year predicted risk.

resultsOf 4432 individuals at a median age of 30.5 years and a median gestational age of 27.9 weeks at pregnancy enrollment, 10.7% developed HDP and 13.7% developed GDM. At 10-14 years after delivery, individuals with HDP had a higher 10-year predicted risk of ASCVD (least squares mean: 2.9% vs. 2.2%; adj. β: 0.59; 95% CI: 0.41-0.77) and a higher 30-year predicted risk of ASCVD (7.7% vs. 6.1%; adj. β: 1.27; 95% CI: 0.81-1.72) compared with those without HDP. Similarly, individuals with GDM had a higher predicted risk of ASCVD (10-year: 3.2% vs. 2.1%; adj. β: 0.51; 95% CI: 0.34-0.67 and 30-year: 8.8% vs. 5.8%; adj. β: 1.56; 95% CI: 1.11-2.01) compared with those without GDM. These results were similar when predicted ASCVD risk was assessed at thresholds of ≥7.5% at 10 years and ≥20% at 30 years.

conclusionIndividuals who experienced HDP or GDM had a higher predicted 10- and 30-year risk of ASCVD measured 10-14 years after delivery compared with individuals who did not experience these APOs.

Indexed as

Cardiovascular DiseasesDiabetes, GestationalHypertension, Pregnancy-InducedAdultFemaleFollow-Up StudiesHumansPregnancyPregnancy OutcomeProspective StudiesRisk Factorsadverse pregnancy outcomescardiovascular diseasecardiovascular healthgestational diabetes mellitushypertensive disorders of pregnancypostpartumpregnancy

Identifiers

PMID39825470
PMCPMC12005981

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.