Evidence map›Paper›PMID 39825928›Full record

ArticleRheumatology international2025

Cerebrovascular risk in rheumatoid arthritis patients: insights from carotid artery atherosclerosis in the Paracelsus 10,000 study.

Mathias Ausserwinkler, Sophie Gensluckner, Vanessa Frey, Isabella Gostner, Bernhard Paulweber, Eugen Trinka, Patrick Langthaler, Christian Datz, Bernhard Iglseder, Jens Thiel and 4 more

Abstract read
In one paragraph

Article in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Stroke in autoimmune rheumatic diseases.Rheumatology international · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mathias AusserwinklerDepartment of Internal Medicine, Elisabethinen Hospital Klagenfurt, Klagenfurt, Austria.ORCID 0009-0000-3353-8702
Sophie GenslucknerFirst Department of Medicine, Paracelsus Medical University, Salzburg, Austria.ORCID 0009-0006-5008-7134
Vanessa FreyDepartment of Neurology, Neurointensive Care and Neurorehabilitation, Member of the European Reference Network EpiCARE, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-5337-1273
Isabella GostnerDepartment of Neurology, Neurointensive Care and Neurorehabilitation, Member of the European Reference Network EpiCARE, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria.
Bernhard PaulweberFirst Department of Medicine, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-1609-4676
Eugen TrinkaDepartment of Neurology, Neurointensive Care and Neurorehabilitation, Member of the European Reference Network EpiCARE, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-5950-2692
Patrick LangthalerDepartment of Neurology, Neurointensive Care and Neurorehabilitation, Member of the European Reference Network EpiCARE, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria.ORCID 0009-0007-7226-8371
Christian DatzDepartment of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0001-7838-4532
Bernhard IglsederDepartment of Geriatric Medicine, University Hospital Salzburg (SALK-Campus CDK), Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-6132-8670
Jens ThielDivision of Rheumatology and Clinical Immunology, Department of Internal Medicine, Medical University, Graz, Austria.ORCID 0000-0001-7582-1514
Hans-Joerg NeumannDepartment of Internal Medicine, Elisabethinen Hospital Klagenfurt, Klagenfurt, Austria.
Maria FlammInstitute of General Practice, Family Medicine and Preventive Medicine, Center for Public Health and Healthcare Research, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0003-0816-6657
Elmar AignerFirst Department of Medicine, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0003-0310-0536
Bernhard WernlyDepartment of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria. bernhard.wernly@pmu.ac.at.ORCID 0000-0003-4024-0220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation. While RA primarily affects the joints, its systemic effects may lead to an increased cerebro- and cardiovascular risk. Atherosclerosis of the carotid arteries is a significant risk factor for cerebrovascular events and serves as a surrogate marker for cardiovascular risk. This study explores the link between RA and carotid artery atherosclerosis with data from the Paracelsus 10,000 Study. Baseline assessments were conducted on individuals randomly selected from Salzburg and its surrounding regions. Participants diagnosed with RA based on ACR-EULAR classification criteria and who underwent carotid artery ultrasound were included. Data were gathered from a total of 9729 participants, among whom 299 were diagnosed with RA. Carotid arteries were examined using ultrasound imaging. The primary endpoint was the difference in the prevalence of plaque presence between the RA and non-RA groups. One univariate (Model I) and three multivariate analyses were conducted, with adjustments in Model II incorporating SCORE 2, while Model III accounted for metabolic syndrome, age and sex. Additionally, Model IV included further adjustments for high-sensitivity C-reactive protein (hs-CRP). Plaque presence was defined as the ultrasound detection of plaque formation larger than 0 mm

Indexed as

Arthritis, RheumatoidCarotid Artery DiseasesCerebrovascular DisordersAdultAgedCarotid ArteriesCarotid Intima-Media ThicknessCarotid StenosisC-Reactive ProteinFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPrevalenceRisk AssessmentC-Reactive ProteinAutoimmune diseaseCardiovascular risk factorsCarotid artery atherosclerosisCerebrovascular riskChronic inflammationIntima-media thicknessLDL cholesterolMetabolic syndromeParacelsus 10,000 studyPlaque formationRheumatoid arthritisStroke riskSystemic inflammationTotal plaque areaUltrasound imaging

Identifiers

PMID39825928
PMCPMC11742769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.