Trial reportSleep2025
Impact and mechanisms of cognitive behavioral therapy for insomnia on fatigue among cancer survivors: a secondary analysis of a randomized controlled trial.
Trial report in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04026048 (A Randomized Controlled Trial of Online Cognitive Behavior Therapy for Insomnia), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Online Cognitive Behavior Therapy for Insomnia (CBT-I) and Perceived Cognitive Impairment (PCI) in Cancer Survivors
Who cites it
6 citing papers in PubMed.
- Cognitive Behavioral Therapy for Cancer-Related Fatigue: A Comparison Between Patients Treated With Curative Intent and Patients With Advanced Cancer.Psycho-oncology · 2025Trial
- Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- A review of neurophysiological relationships between sleep disorders and depression.Brain, behavior, & immunity - health · 2026Review
- Pharmacologic management of postoperative sleep disturbance in breast cancer.Frontiers in pharmacology · 2026Review
- Comparative efficacy of aerobic exercise and mind-body practices in improving sleep quality and psychological distress among elderly breast cancer patients: a systematic review.Frontiers in oncology · 2026Review
- Internet-delivered cognitive behavioral therapy versus standard information brochures in advanced cancer caregivers: randomized controlled trial.Internet interventions · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesCancer-related fatigue is one of the most common symptoms in cancer survivors. Cognitive behavioral therapy for insomnia (CBT-I) can improve fatigue, but mechanisms are unclear. This secondary analysis of a randomized controlled trial evaluated whether CBT-I led to a significant improvement in fatigue, accounting for change in comorbid symptoms of insomnia, perceived cognitive impairment (PCI), anxiety, and depression. The parent study evaluated the impacts of CBT-I on PCI and insomnia.
methodsCancer survivors with insomnia and PCI were randomized to CBT-I or sleep-self-monitoring waitlist control. Fatigue was measured using the Multidimensional Fatigue Symptom Inventory-Short Form at pre-, mid-, and post-treatment. Significant improvement in fatigue was defined as a reduction of >10.79 points. Insomnia, PCI, anxiety, and depression symptoms were assessed. A linear mixed model evaluated whether CBT-I improved fatigue after adjusting for comorbidities. Mediation analyses examined whether change in comorbidities accounted for the effect of CBT-I on fatigue.
resultsThe sample consisted of 132 cancer survivors (77% female, Mage = 60.12 years, 41% breast cancer). There was a significant group-by-time interaction on fatigue, p < .001, with the CBT-I group experiencing a 20.6-point reduction in fatigue compared to 3.7 points in the control. Improvements in fatigue were fully accounted for by improvements in the comorbidities with change in insomnia accounting for 45.3% of the effect observed in fatigue.
conclusionsCBT-I resulted in significant improvement in fatigue, and these effects were largely accounted for by changes in insomnia. CBT-I is a robust intervention with efficacy for improving fatigue among cancer survivors. CLINICAL TRIAL INFORMATION: Online Treatment of Cognitive Impairment and Insomnia in Cancer Survivors, https://clinicaltrials.gov/study/NCT04026048?term=NCT04026048&rank=1, ClinicalTrials.gov ID: NCT04026048.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.