Evidence map›Paper›PMID 39827433›Full record

ArticleThe Journal of membrane biology2025

Computational Insights on the Assembly of the Dengue Virus Membrane-Capsid-RNA Complex.

Dwaipayan Chaudhuri, Satyabrata Majumder, Joyeeta Datta, Kalyan Giri

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. New Advances in Small Molecules Targeted at Viral Capsid-Genome Binding.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dwaipayan ChaudhuriDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.
Satyabrata MajumderDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.
Joyeeta DattaDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.
Kalyan GiriDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India. kalyan.dbs@presiuniv.ac.in.ORCID 0000-0001-5681-2612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus, an arbovirus from the genus Flavivirus in the family Flaviviridae, forms a nucleocapsid structure through interactions between its genome and multiple copies of the capsid protein. Experimental studies have confirmed the interaction between the viral capsid protein and lipid droplets, indicating a protein-lipid interaction. Cryo-EM studies show that in immature viruses, the nucleocapsid is located close to the viral membrane. This study uses multiple MD simulations to explore the orientation of the capsid protein relative to the lipid membrane, focusing on how the protein's hydrophobic pocket interacts with the membrane. We also investigated the interaction between the capsid protein and RNA, considering the effects of sequence length and identity. Finally, we construct a model of the lipid-protein-RNA complex, demonstrating that the capsid protein's hydrophobic pocket interacts with the membrane, while the positively charged H4 helix interacts with the negatively charged RNA. This research may identify crucial interactions for immature virus particle formation and provide insights for future therapeutic interventions.

Indexed as

CapsidCapsid ProteinsDengue VirusRNA, ViralVirus AssemblyHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationProtein BindingCapsid ProteinsRNA, ViralCapsid–lipid interactionCapsid–RNA interactionDengue virusMD simulationNucleocapsid

Identifiers

PMID39827433

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.