ArticleAsia Pacific journal of clinical nutrition2025
Association between serum copper concentration and body composition in children with spinal muscular atrophy: a cross-sectional study.
Article in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Malnutrition and associated geriatric syndromes in older outpatients: A comprehensive analysis.Asia Pacific journal of clinical nutrition · 2026Article
- Epigenetic regulation in spinal muscular atrophy: emerging areas and future directions.Orphanet journal of rare diseases · 2025Review
- Biomarkers in spinal muscular atrophy.Frontiers in neurology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
BACKGROUND AND
objectivesThe role of serum copper in modulating body composition in patients with spinal muscular atrophy (SMA) remains uncertain. This study aimed to illustrate the correlation between serum copper concentration and body composition in children with SMA. METHODS AND STUDY
designThis study was conducted at a pediatric medical center in China from July 2019 to August 2022. The study included anthropometric measurements, serum analysis for copper, magnesium, zinc, and iron, as well as comprehensive body composition assessments. Multivariate analysis was utilized to assess the connection between serum copper concentration and body composition metrics.
resultsThis cross-sectional analysis included 87 patients [median (IQR) age: 7 years (5-10), 57.5% male] diagnosed with SMA receiving comprehensive multi-disciplinary management. The results revealed a positive association between serum copper concentration and both fat mass percentage (β = 0.50, 95% confidence interval (CI): 0.07 to 0.92, p = 0.025) and fat-muscle ratio (β = 0.02, 95% CI: 0.01 to 0.03, p = 0.009). Conversely, a negative correlation was found between serum copper concentration and muscle mass percentage (β = -0.70, 95% CI: -1.11 to -0.29, p = 0.001).
conclusionsThese findings suggest a correlation between copper concentration and body composition in SMA, offering valuable insights for addressing metabolic dysregulation in these patients.
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