Evidence mapPaperPMID 39829307Full record

ArticleJournal of diabetes investigation2025

Imeglimin, unlike metformin, does not perturb differentiation of human induced pluripotent stem cells towards pancreatic β-like cells and rather enhances gain in β cell identity gene sets.

Tasuku Imada, Shugo Sasaki, Hiroki Yamaguchi, Ayaka Ueda, Dan Kawamori, Naoto Katakami, Iichiro Shimomura

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Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tasuku ImadaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Shugo SasakiDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0002-3696-7809
Hiroki YamaguchiDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Ayaka UedaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Dan KawamoriDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0002-0149-8213
Naoto KatakamiDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0001-9020-8320
Iichiro ShimomuraDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Funding

iPS Academia JapanJapan Diabetes FoundationJapan Diabetes SocietyJapan IDDM networkJapan Society for the Promotion of Science JP21K08576Japan Society for the Promotion of Science JP21K20902Japan Society for the Promotion of Science JP22K16395Kanae Foundation for the Promotion of Medical ScienceManpei Suzuki Diabetes FoundationOsaka Medical Research Foundation for Intractable DiseasesTakeda Science Foundation
6 · The paper itself

Abstract

AIMS/

introductionMetformin treatment for hyperglycemia in pregnancy (HIP) beneficially improves maternal glucose metabolism and reduces perinatal complications. However, metformin could impede pancreatic β cell development via impaired mitochondrial function. A new anti-diabetes drug imeglimin, developed based on metformin, improves mitochondrial function. Here we examine the effect of imeglimin on β cell differentiation using human induced pluripotent stem cell (iPSC)-derived pancreatic islet-like spheroid (SC-islet) models. MATERIALS AND

methodsHuman iPSCs are differentiated into SC-islets by three-dimensional culture with and without imeglimin or metformin. Differentiation efficiencies of SC-islets were analyzed by flow cytometry, immunostaining, quantitative PCR, and insulin secretion assay. RNA sequencing and oxygen consumption rate were obtained for further characterization of SC-islets. SC-islets were cultured with proinflammatory cytokines, in part mimicking the uterus environment in HIP.

resultsMetformin perturbed SC-islet differentiation while imeglimin did not alter it. Furthermore, imeglimin enhanced the gene expressions of β cell lineage markers. Maintenance of mitochondrial function and optimization of TGF-β and Wnt signaling were considered potential mechanisms for augmented β cell maturation by imeglimin. In the presence of proinflammatory cytokines, imeglimin ameliorated β cell differentiation impaired by cytokines and metformin.

conclusionsImeglimin does not perturb differentiation of SC-islet cells and rather enhances gain in β cell identity gene sets in contrast to metformin. This may lead to the improvement of in vitro β cell differentiation protocols.

Indexed as

Cell DifferentiationHypoglycemic AgentsInduced Pluripotent Stem CellsInsulin-Secreting CellsMetforminCells, CulturedHumansHypoglycemic AgentsMetforminImegliminMetforminβ cell differentiation

Identifiers

PMID39829307
PMCPMC11970301

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.