ArticlebioRxiv : the preprint server for biology2025
Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions represent some of the most common perturbations to neural function in animals. Therefore, it is unclear if activity sensing is a universal strategy for different types of perturbations or if stability may arise by sensing specific environmental cues. Here we show the respiratory network of amphibians mounts a fast homeostatic response to restore motor function following inactivity caused by cooling over the physiological range. This response was not initiated by inactivity, but rather, by temperature. Compensation involved cold-activation of the noradrenergic system
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