Evidence map›Paper›PMID 39829793›Full record

ArticlebioRxiv : the preprint server for biology2025

Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila.

Shweta Yadav, Xingxiu Pan, Shengxi Li, Paige LaRae Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L Zuckerman, Subrata Munan and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shweta YadavAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9760-3382
Xingxiu PanScintillon Institute, Laboratory of Redox Biology and Metabolism, San Diego, CA.
Shengxi LiState Key Laboratory of Common Mechanism Research for Major Disease, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Paige LaRae MartinAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.
Ngoc HoangAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.
Kejin ChenAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.
Aditi KarhadkarAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.
Jatin MalhotraAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.
Austin L ZuckermanScintillon Institute, Laboratory of Redox Biology and Metabolism, San Diego, CA.
Subrata MunanScintillon Institute, Laboratory of Redox Biology and Metabolism, San Diego, CA.
Markus K KloseDepartment of Pharmacology & Chemical Biology, University of Pittsburgh, PA, USA.ORCID 0000-0001-5861-2366
Lin WangState Key Laboratory of Common Mechanism Research for Major Disease, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Valentin CracanScintillon Institute, Laboratory of Redox Biology and Metabolism, San Diego, CA.ORCID 0000-0002-3280-0593
Andrey A ParkhitkoAging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9852-8329

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Expanding the set of genetically encoded tools for compartment-specific manipulation of redox metabolism in living cellsR35GM142495 · NIGMS · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI Valentin Cracan · 2021 to 2026
$3.2M
Deciphering the crosstalk between methionine metabolism and methyltransferases in health and diseaseR35GM146869 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Andrey A Parkhitko · 2022 to 2026
$2.3M
Methionine Cycle as a Mechanistic Hub for the Hallmarks of AgingR01AG082801 · NIA · BROWN UNIVERSITY · PI Andrey A Parkhitko, MARC TATAR · 2023 to 2026
$1.7M
NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of mitochondrial electron transport chain with artificial and endogenous substratesR21AG085012 · NIA · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI CRACAN, VALENTIN · 2023 to 2023
$530k
Defining and targeting the compartmentalization of redox metabolism in aging using novel genetically encoded toolsR03AG067301 · NIA · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI CRACAN, VALENTIN · 2020 to 2021
$192k
Tyrosine degradation pathway in mitochondrial dysfunction and agingR03AG075651 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARKHITKO, ANDREY A · 2022 to 2023
$159k
Combined targeting of synthetic lethal partners in RB1-deficient cellsR03CA286521 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARKHITKO, ANDREY A · 2024 to 2025
$159k
NCI NIH HHS R03 CA286521NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG082801NIA NIH HHS R03 AG067301NIA NIH HHS R03 AG075651NIA NIH HHS R21 AG085012NIGMS NIH HHS R35 GM142495NIGMS NIH HHS R35 GM146869
6 · The paper itself

Abstract

Aging is characterized by extensive metabolic dysregulation. Redox coenzyme nicotinamide adenine dinucleotide (NAD) can exist in oxidized (NAD

Indexed as

agingB-mediated reductive stressDrosophilaLbNOXmitochondriamutated α-crystallinNAD+NADHNADP+NADPHxenotopic tool

Identifiers

PMID39829793
PMCPMC11741393

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.