Evidence map›Paper›PMID 39829825›Full record

ArticlebioRxiv : the preprint server for biology2025

Reduced enteric BDNF-TrkB signaling drives stress-dependent glucocorticoid-mediated GI dysmotility.

Jared Slosberg, Srinivas N Puttapaka, Philippa Seika, Su Min Hong, Alpana Singh, Ainsleigh Scott, Subhash Kulkarni

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jared SlosbergDepartment of Genetic Medicine, Johns Hopkins University - School of Medicine, Baltimore, MD, USA.
Srinivas N PuttapakaDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Philippa SeikaDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Su Min HongDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Alpana SinghCleveland Clinic, Cleveland.
Ainsleigh ScottDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Subhash KulkarniDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115.ORCID 0000-0002-2298-0623

Funding

Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous SystemR01AG066768 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOFF, LOYAL ANDREW, KULKARNI, SUBHASH · 2021 to 2025
$3.3M
Predoctoral Training Program in Human GeneticsT32GM148383 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Kimberly F Doheny, ANDREW S MCCALLION · 2023 to 2026
$2.4M
Developing a Microphysiological System of a Humanized Gut-Brain-Axis for Ageassociated Transmissible NeuropathologiesR21AG072107 · NIA · JOHNS HOPKINS UNIVERSITY · PI KOPPES, ABIGAIL NELSON, KULKARNI, SUBHASH · 2022 to 2023
$484k
NIA NIH HHS R01 AG066768NIA NIH HHS R21 AG072107NIGMS NIH HHS T32 GM148383
6 · The paper itself

Abstract

Stress is a key contributor to gastrointestinal (GI) dysmotility, particularly in patients with disorders of gut-brain interactions (DGBI). Since GI motility is governed by the enteric nervous system (ENS), stress may act by altering ENS function. While stress activates glucocorticoid signaling via the hypothalamic-pituitary-adrenal axis, the impact of stress-mediated glucocorticoid signaling on ENS biology remains poorly understood. In the central nervous system, glucocorticoids reduce specific isoforms of brain-derived neurotrophic factor (BDNF), impairing signaling through its receptor, TrkB, and contributing to behavioral dysfunction. However, the identity of ENS-specific

Identifiers

PMID39829825
PMCPMC11741244

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.