Evidence map›Paper›PMID 39829933›Full record

ArticlebioRxiv : the preprint server for biology2025

Ramp sequence may explain synonymous variant association with Alzheimer's disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (

Justin B Miller, J Anthony Brandon, Lauren M McKinnon, Hady W Sabra, Chloe C Lucido, Josue D Gonzalez Murcia, Kayla A Nations, Samuel H Payne, Mark T W Ebbert, John S K Kauwe and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Justin B MillerDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0002-5309-1570
J Anthony BrandonSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Lauren M McKinnonDepartment of Biology, Brigham Young University, Provo, UT 84602.
Hady W SabraDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40506, USA.
Chloe C LucidoDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40506, USA.
Josue D Gonzalez MurciaDepartment of Biology, Brigham Young University, Provo, UT 84602.
Kayla A NationsSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Samuel H PayneDepartment of Biology, Brigham Young University, Provo, UT 84602.
Mark T W EbbertSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
John S K KauweDepartment of Biology, Brigham Young University, Provo, UT 84602.
Perry G RidgeDepartment of Biology, Brigham Young University, Provo, UT 84602.

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Using long-range technologies as a multi-omic approach to understand Alzheimer’s disease in brain tissueR01AG068331 · NIA · UNIVERSITY OF KENTUCKY · PI EBBERT, MARK T W · 2020 to 2024
$3.0M
Understanding how structural mutations and individual RNA isoformsare involved in human health and diseaseR35GM138636 · NIGMS · UNIVERSITY OF KENTUCKY · PI Mark T W Ebbert · 2020 to 2026
$2.9M
NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG068331NIGMS NIH HHS R35 GM138636
6 · The paper itself

Abstract

backgroundSynonymous variant

objectiveWe hypothesized that

methodsWe assessed

resultsBoth mRNA (

conclusionsWe show that

Indexed as

Alzheimer’s diseasecodon usage biasdisease associationgenetic associationramp sequence

Identifiers

PMID39829933
PMCPMC11741268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.