Evidence map›Paper›PMID 39830040›Full record

ArticleEuropean cells & materials

DESIGNER FAT CELLS: ADIPOGENIC DIFFERENTIATION OF CRISPR-CAS9 GENOME-ENGINEERED INDUCED PLURIPOTENT STEM CELLS.

E V Ely, A T Kapinski, S G Paradi, R Tang, F Guilak, K H Collins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European cells & materials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

E V ElyDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
A T KapinskiDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
S G ParadiDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
R TangDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
F GuilakDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
K H CollinsDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · WASHINGTON UNIVERSITY · 1999 to 2025
$5.7M
VISCOELASTIC PROPERTIES OF NORMAL AND OA CHONDRONSR01AG015768 · DUKE UNIVERSITY · 1998 to 2005
$1.7M
Genetically-engineered stem cells for self-regulating arthritis therapyR01AR080902 · WASHINGTON UNIVERSITY · 2025 to 2025
$725k
Washington University Rheumatic Diseases Research Resource-based CenterP30AR073752 · WASHINGTON UNIVERSITY · 2025 to 2025
$700k
RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINEP30AR074992 · WASHINGTON UNIVERSITY · 2025 to 2025
$641k
The Role of Fat in OsteoarthritisR00AR078949 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$224k
The Multiscale Role of Piezo Channels in Obesity-Associated Cartilage DamageF31AR079260 · WASHINGTON UNIVERSITY · 2025 to 2025
$50k
NIAMS NIH HHS F31 AR079260NIAMS NIH HHS K99 AR078949NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R00 AR078949NIAMS NIH HHS R01 AR072999NIAMS NIH HHS R01 AR080902NIA NIH HHS R01 AG015768NIA NIH HHS R01 AG046927NIDDK NIH HHS P30 DK056341NIDDK NIH HHS T32 DK108742
6 · The paper itself

Abstract

Adipose tissue is an active endocrine organ that can signal bidirectionally to many tissues and organ systems in the body. With obesity, adipose tissue can serve as a source of low-level inflammation that contributes to various co-morbidities and damage to downstream effector tissues. The ability to synthesize genetically engineered adipose tissue could have critical applications in studying adipokine signaling and the use of adipose tissue for novel therapeutic strategies. This study aimed to develop a method for non-viral adipogenic differentiation of genome-edited murine induced pluripotent stem cells (iPSCs) and to test the ability of such cells to engraft in mice

Indexed as

adipocyte differentiationadipokine secretionadipose tissuecell-based therapiesfunctional adipocytesObesitytissue engineering

Identifiers

PMID39830040
PMCPMC11741189

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.