Evidence map›Paper›PMID 39831934›Full record

ReviewCancer metastasis reviews2025

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in "microenvironmental-ity".

Ariana Sattler, Tetiana Korzun, Kasmira Gupta, Parham Diba, Natasha Kyprianou, Sebnem Ece Eksi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  3. Review
  4. Neuro-tumor interactions in peripheral tumors.Cancer metastasis reviews · 2026
    Review
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  6. Review
  7. Review
  8. Article
  9. Review
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  12. Review
  13. The authors respond to feedback onFrontiers in oncology · 2026
    Article
  14. Review
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ariana SattlerCancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-1699-4743
Tetiana KorzunDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 S Moody Avenue, Portland, OR, 97201, USA.
Kasmira GuptaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Parham DibaDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR, 97239, USA.ORCID 0000-0003-1014-510X
Natasha KyprianouDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID 0000-0002-8713-3599
Sebnem Ece EksiCancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. eksi@ohsu.edu.ORCID 0000-0003-1012-5571

Funding

Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University Full 2022-1494
6 · The paper itself

Abstract

Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upon injury and cancer onset, this review specifically focuses on how sympathetic nerves rewire the TME. Within tumors, sympathetic nerves closely interact with various TME components, and their combined signaling often shifts tumor-intrinsic physiology toward tumor-supportive phenotypes. In turn, the TME components, such as myeloid cells, lymphoid cells, extracellular matrix (ECM), endothelial cells, cancer associated fibroblasts (CAFs), and Schwann cells, secrete neurotrophic and axon guidance factors that influence both sympathetic outgrowth and tumor cell behavior, further exacerbating tumor progression and metastasis. Here, we review the current evidence on the multidirectional impacts of sympathetic nerves and both immune and non-immune TME components, the nature of these communication processes, and how exploring these interactions may inform future therapeutics to impair cancer progression and metastasis.

Indexed as

NeoplasmsSympathetic Nervous SystemTumor MicroenvironmentAnimalsHumansSignal TransductionCancer neuroscienceNeuro-immune axisSympathetic signalingTumor microenvironment

Identifiers

PMID39831934
PMCPMC11753337

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.