Evidence map›Paper›PMID 39832015›Full record

ArticlePsychopharmacology2025

D

Hannah LaCourse, Lily Bennett, April Falstad, Francesca Asmus, Meghan Smith, Ravin Davis, Kylee Harrington, Denise Giuvelis, Tamara King, Glenn W Stevenson

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannah LaCourseDepartment of Psychology, University of New England, Biddeford, ME, USA.
Lily BennettDepartment of Psychology, University of New England, Biddeford, ME, USA.
April FalstadDepartment of Psychology, University of New England, Biddeford, ME, USA.
Francesca AsmusDepartment of Psychology, University of New England, Biddeford, ME, USA.
Meghan SmithDepartment of Psychology, University of New England, Biddeford, ME, USA.
Ravin DavisDepartment of Psychology, University of New England, Biddeford, ME, USA.
Kylee HarringtonDepartment of Psychology, University of New England, Biddeford, ME, USA.
Denise GiuvelisBehavior Core, COBRE, University of New England, Biddeford, ME, USA.
Tamara KingDepartment of Physiology, College of Osteopathic Medicine, University of New England, Biddeford, ME, USA.
Glenn W StevensonDepartment of Psychology, University of New England, Biddeford, ME, USA. gstevenson@une.edu.ORCID http://orcid.org/0000-0002-5869-3714

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
NIGMS NIH HHS P20 GM103643NIGMS NIH HHS P20GM103643
6 · The paper itself

Abstract

RATIONALE AND

objectivesIn vivo receptor interactions vary as a function of behavioral endpoint, with key differences between reflexive and non-reflexive measures that assess the motivational aspects of pain and pain relief. There have been no assessments of D

methodsSKF82958 and methadone were used as selective/high efficacy D

resultsMethadone alone, but not SKF82958 alone, produced dose-dependent restoration of pain-depressed responding. Both SKF82958 and methadone produced dose-dependent response rate suppression. Three fixed proportion mixtures, based on the relative potencies of the drugs in the rate suppression assay, produced dose-dependent antinociception and sedation. Isobolographic analysis indicated that the 0.17:1 mixture produced supra-additive antinociception and additive sedation. The 0.055:1 mixture produced additive antinociception with sub-additive sedation, and the 0.018:1 mixture had the highest therapeutic index (TI) relative to other mixtures and drugs alone. The antinociceptive doses and component doses for the 0.018:1 mixture did not produce conditioned place preference.

conclusionsThese results suggest that D

Indexed as

Conditioning, OperantMethadonePainReceptors, Dopamine D1Receptors, Opioid, muAnalgesics, OpioidAnimalsBenzazepinesDopamine AgonistsDose-Response Relationship, DrugMaleRatsRats, Sprague-DawleyRewardAnalgesics, OpioidBenzazepinesDopamine AgonistsMethadoneReceptors, Dopamine D1Receptors, Opioid, muSK&F 82958D1 receptorDopamine receptorMethadoneOperant conditioningOpioid receptorOpioid sparingPain-depressed behaviorsReceptor interactions

Identifiers

PMID39832015

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.