Evidence map›Paper›PMID 39832889›Full record

ArticleBMJ open respiratory research2025

Protease-activated receptor 1 in the pathogenesis of cystic fibrosis.

Sohinee Sarkar, Jia-Xi Han, Kristy Azzopardi, Poshmaal Dhar, Muhammad A Saeed, Sophie Day, Sarath Ranganathan, Philip Sutton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sohinee SarkarMurdoch Children's Research Institute, Parkville, Victoria, Australia sohinee.sarkar@mcri.edu.au.ORCID http://orcid.org/0000-0001-9364-1920
Jia-Xi HanMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Kristy AzzopardiMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Poshmaal DharMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Muhammad A SaeedMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Sophie DayMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Sarath RanganathanMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Philip SuttonMurdoch Children's Research Institute, Parkville, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most common cause of death in those with cystic fibrosis (CF) is respiratory failure due to bronchiectasis resulting from repeated cycles of respiratory infection and inflammation. Protease-activated receptor 1 (PAR1) is a cell surface receptor activated by serine proteases including neutrophil elastase, which is recognised as a potent modulator of inflammation. While PAR1 is known to play an important role in regulating inflammation, nothing is known about any potential role of this receptor in CF pathogenesis.

methodsPAR1 (

results

conclusionsThis study provides the first evidence of PAR1 contributing to the pathological effects of

Indexed as

Cystic FibrosisReceptor, PAR-1AnimalsColonCystic Fibrosis Transmembrane Conductance RegulatorDisease Models, AnimalIleumLungMaleMiceMice, KnockoutCftr protein, mouseCystic Fibrosis Transmembrane Conductance RegulatorReceptor, PAR-1Cystic FibrosisInflammation

Identifiers

PMID39832889
PMCPMC12004468

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.