ArticleBMJ open respiratory research2025
Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.
Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lung capacity is a determinant of cardiovascular disease and myocardial infarction.Respiratory research · 2026Article
- Association of life's essential 8 with pulmonary function impairment: a cross-sectional analysis of the Kailuan study.Frontiers in nutrition · 2026Article
- Joint associations of lung function of both general and abdominal obesity with cardiometabolic multimorbidity: a cross-sectional study.Frontiers in medicine · 2026Article
- Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study.The European respiratory journal · 2025Article
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Authors and funding
25 authors.
Funding
Abstract
introductionPrevious population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.
methodsThe study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments. Postbronchodilator forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC were measured at baseline. Participants who reported having doctor-diagnosed hypertension, diabetes, heart disease and stroke at follow-up but not at baseline were considered new cases of these diseases. The association between lung function and the onset of participant-reported cardiometabolic diseases was assessed in each site using regression models, and estimates were combined using random effects meta-analysis. Models were adjusted for sex, age, smoking, body mass index and educational level.
resultsParticipants with greater per cent predicted FVC were less likely to have new-onset diabetes (OR per 10%=0.91, 95% CI 0.84 to 0.99), heart disease (OR per 10%=0.86, 95% CI 0.80 to 0.92) and stroke (OR per 10%=0.81, 95% CI 0.73 to 0.89) during the follow-up period (mean±SD 9.5±3.6 years). A greater percentage of FEV
conclusionsThe findings of this study suggest that a low FVC is more important than a low FEV
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