Evidence map›Paper›PMID 39833263›Full record

ArticleScientific reports2025

Contrasting vector competence of three main East African Anopheles malaria vector mosquitoes for Plasmodium falciparum.

Prisca A Kweyamba, Lorenz M Hofer, Ummi A Kibondo, Rehema Y Mwanga, Rajabu M Sayi, Fatuma Matwewe, Dickson W Lwetoijera, Mgeni M Tambwe, Sarah J Moore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. "Target species complex" concept: Strengthening environmental risk assessment of engineered gene drives.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Estimating mosquito bionomics parameters with a hierarchical Bayesian model.Current research in parasitology & vector-borne diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Prisca A KweyambaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania. pkweyamba@ihi.or.tz.
Lorenz M HoferSwiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123, Allschwil, Switzerland.
Ummi A KibondoEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Rehema Y MwangaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Rajabu M SayiEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Fatuma MatweweEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Dickson W LwetoijeraEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Mgeni M TambweEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.
Sarah J MooreEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are three Anopheles mosquito species in East Africa that are responsible for the majority of malaria transmission, posing a significant public health concern. Understanding the vector competence of different mosquito species is crucial for targeted and cost-effective malaria control strategies. This study investigated the vector competence of laboratory reared strains of East African An. gambiae sensu stricto, An. funestus s.s., and An. arabiensis mosquitoes towards local isolates of Plasmodium falciparum infection. Mosquito feeding assays using gametocytaemic blood from local donors revealed significant differences in both prevalence and intensity of oocyst and sporozoite infections among the three vectors. An. funestus mosquitoes presented the highest sporozoite prevalence 23.5% (95% confidence interval (CI) 17.5-29.6) and intensity of infection 6-58138 sporozoites. Relative to An. funestus, the odds ratio for sporozoites prevalence were 0.46 (95% CI 0.25-0.85) in An. gambiae and 0.19 (95% CI 0.07-0.51) in An. arabiensis, while the incidence rate ratio for sporozoite intensity was 0.31 (95% CI 0.14-0.69) in An. gambiae and 0.66 (95% CI 0.16-2.60) in An. arabiensis. Our findings indicate that all three malaria vector species may contribute to malaria transmission in East Africa, with An. funestus demonstrating superior vector competence. In conclusion, there is a need for comprehensive malaria control strategies targeting major malaria vector species, an update of malaria transmission models to consider vector competence and evaluation of malaria transmission blocking interventions in assays that include An. funestus mosquitoes.

Indexed as

AnophelesMalaria, FalciparumMosquito VectorsPlasmodium falciparumAfrica, EasternAnimalsFemaleHumansSporozoites

Identifiers

PMID39833263
PMCPMC11747171

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.