Evidence map›Paper›PMID 39833457›Full record

ReviewNature reviews. Neurology2025

Imperatives and co-benefits of research into climate change and neurological disease.

Medine I Gulcebi, Sara Leddy, Katherine Behl, Derk-Jan Dijk, Eve Marder, Mark Maslin, Anna Mavrogianni, Michael Tipton, David J Werring, Sanjay M Sisodiya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Stroke and climate change: A World Stroke Organization scientific statement.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  5. Review
  6. Neurobiophilia.Brain sciences · 2026
    Review
  7. Review
  8. Article
  9. Medications, epilepsy and climate change: Added layers of complexity.British journal of clinical pharmacology · 2025
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Medine I GulcebiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Sara LeddyDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Katherine BehlAlternating Hemiplegia of Childhood UK, Southampton, UK.ORCID 0009-0005-9020-0384
Derk-Jan DijkSurrey Sleep Research Centre, University of Surrey, Guildford, UK.ORCID 0000-0001-5314-1008
Eve MarderBiology Department and Volen Center, Brandeis University, Waltham, MA, USA.ORCID 0000-0001-9632-5448
Mark MaslinDepartment of Geography, University College London, London, UK.
Anna MavrogianniInstitute for Environmental Design and Engineering, Bartlett School of Environment, Energy and Resources, Bartlett Faculty of the Built Environment, University College London, London, UK.
Michael TiptonExtreme Environments Laboratory, University of Portsmouth, Portsmouth, UK.
David J WerringStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0003-2074-1861
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK. s.sisodiya@ucl.ac.uk.ORCID 0000-0002-1511-5893

Funding

Neuromodulation and Robustness of Neurons and NetworksR35NS097343 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 2017 to 2024
$7.8M
NINDS NIH HHS R35 NS097343
6 · The paper itself

Abstract

Evidence suggests that anthropogenic climate change is accelerating and is affecting human health globally. Despite urgent calls to address health effects in the context of the additional challenges of environmental degradation, biodiversity loss and ageing populations, the effects of climate change on specific health conditions are still poorly understood. Neurological diseases contribute substantially to the global burden of disease, and the possible direct and indirect consequences of climate change for people with these conditions are a cause for concern. Unaccustomed temperature extremes can impair the systems of resilience of the brain, thereby exacerbating or increasing susceptibility to neurological disease. In this Perspective, we explore how changing weather patterns resulting from climate change affect sleep - an essential restorative human brain activity, the quality of which is important for people with neurological diseases. We also consider the pervasive and complex influences of climate change on two common neurological conditions: stroke and epilepsy. We highlight the urgent need for research into the mechanisms underlying the effects of climate change on the brain in health and disease. We also discuss how neurologists can respond constructively to the climate crisis by raising awareness and promoting mitigation measures and research - actions that will bring widespread co-benefits.

Indexed as

Biomedical ResearchClimate ChangeNervous System DiseasesHumans

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.