Evidence map›Paper›PMID 39833555›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

Upregulation of Piezo2 and increased extracellular matrix protein in diabetic kidney disease mice.

Rina Oba, Hitoshi Ueno, Atsuro Oishi, Kiyotaka Nagahama, Go Kanzaki, Nobuo Tsuboi, Takashi Yokoo, Miki Nagase

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies.Journal of experimental & clinical cancer research : CR · 2025
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rina Oba *Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Hitoshi Ueno *Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Atsuro OishiDepartment of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Kiyotaka NagahamaDepartment of Pathology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Go KanzakiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Nobuo TsuboiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Miki NagaseDepartment of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. mnagase@ks.kyorin-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical forces such as glomerular hyperfiltration are crucial in the pathogenesis and progression of diabetic kidney disease. Piezo2 is a mechanosensitive cation channel and plays a major role in various biological and pathophysiological phenomena. We previously reported Piezo2 expression in mouse and rat kidneys and its alteration by dehydration and hypertension. To elucidate the alteration of Piezo2 expression and its consequences in a mouse model of diabetic kidney disease, we used high salt-fed male KK-A

Indexed as

Diabetic NephropathiesExtracellular Matrix ProteinsIon ChannelsAnimalsDisease Models, AnimalFibronectinsHumansMaleMesangial CellsMiceUp-RegulationExtracellular Matrix ProteinsFibronectinsIon ChannelsPiezo2 protein, mouseDiabetic kidney diseaseFibronectinHyperfiltrationMesangial cellsPiezo2

Identifiers

PMID39833555

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.