Evidence map›Paper›PMID 39834231›Full record

ArticleEndocrinology2025

A Dynamic Shift in Estrogen Receptor Expression During Granulosa Cell Differentiation in the Ovary.

Chan Jin Park, Ji-Eun Oh, PoChing Lin, Sherry Zhou, Mary Bunnell, Emmanuel Bikorimana, Michael J Spinella, Hyunjung Jade Lim, CheMyong J Ko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chan Jin ParkDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0001-9008-1964
Ji-Eun OhDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0003-3352-9608
PoChing LinDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0002-0067-7586
Sherry ZhouEpivara, Inc., Research Park, Champaign, IL 61820, USA.ORCID 0000-0001-8587-1734
Mary BunnellDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Emmanuel BikorimanaDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0002-1583-0969
Michael J SpinellaDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0003-3150-3009
Hyunjung Jade LimDepartment of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 05029, Korea.ORCID 0000-0003-2191-666X
CheMyong J KoDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0002-0963-3731

Funding

Ovulation and Luteal Formation in Rodents Monkeys and WomenP01HD071875 · NICHD · UNIVERSITY OF KENTUCKY · PI CURRY, THOMAS E · 2014 to 2018
$6.1M
Conversion of ERalpha cells to ERbeta cells in a cell lineageR21HD094296 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KO, CHEMYONG JAY · 2018 to 2019
$436k
NICHD NIH HHS P01 HD071875NICHD NIH HHS R21 HD094296NIH HHS HD071875
6 · The paper itself

Abstract

This study uncovers a dynamic shift in estrogen receptor expression during granulosa cell (GC) differentiation in the ovary, highlighting a transition from estrogen receptor alpha (ESR1) to estrogen receptor beta (ESR2). Using a transgenic mouse model with Esr1-iCre-mediated Esr2 deletion, we demonstrate that ESR2 expression is absent in GCs derived from ESR1-expressing ovarian surface epithelium (OSE) cells. Single-cell analysis of the OSE-GC lineage reveals a developmental trajectory from Esr1-expressing OSE cells to Foxl2-expressing pre-GCs, culminating in GCs exclusively expressing Esr2. Transcriptome analyses identified vasculature-derived TGFβ1 ligands as key regulators of this transition. Supporting this, TGFβ1 treatment of cultured embryonic ovaries reduced Esr1 expression while promoting Esr2 expression. This study underscores the capability of GCs to switch from ESR1 to ESR2 expression as a fundamental aspect of normal differentiation.

Indexed as

Cell DifferentiationEstrogen Receptor alphaEstrogen Receptor betaGranulosa CellsOvaryAnimalsFemaleForkhead Box Protein L2MiceMice, TransgenicTransforming Growth Factor beta1Esr1 protein, mouseEstrogen Receptor alphaEstrogen Receptor betaForkhead Box Protein L2Foxl2 protein, mouseTransforming Growth Factor beta1cell lineageestrogen receptorsgranulosa cellsovary

Identifiers

PMID39834231
PMCPMC12054734

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.