Evidence mapPaperPMID 39834621Full record

ArticleClinical kidney journal2025

Efficacy and safety of dapagliflozin in patients with CKD: real-world experience in 93 Italian renal clinics.

Roberto Minutolo, Silvio Borrelli, Andrea Ambrosini, Luigi Amoroso, Filippo Aucella, Valentina Batini, Yuri Battaglia, Laura Bregoli, Vincenzo Cantaluppi, Giuseppe Cianciolo and 16 more

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dapagliflozin in Patients With CKD With Fabry Disease.Kidney international reports · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Roberto MinutoloNephrology and Dialysis Unit, Department of Advanced Medical and Surgical Sciences, University of Campania, Naples, Italy.ORCID https://orcid.org/0000-0001-5686-2089
Silvio BorrelliNephrology and Dialysis Unit, Department of Advanced Medical and Surgical Sciences, University of Campania, Naples, Italy.
Andrea AmbrosiniNephrology and Dialysis Unit, ASST dei Sette Laghi, Varese, Italy.
Luigi AmorosoNephrology and Dialysis Unit, "G. Mazzini" Hospital, Teramo, Italy.
Filippo AucellaNephrology and Dialysis Unit, Casa Sollievo della Sofferenza Foundation, San Giovanni Rotondo, Italy.ORCID https://orcid.org/0000-0003-1027-7049
Valentina BatiniNephrology Unit ASL Toscana NordOvest, Livorno, Italy.
Yuri BattagliaDepartment of Medicine, University of Verona, Verona, Italy.
Laura BregoliNephrology Unit, ASST Spedali Civili Brescia.
Vincenzo CantaluppiNephrology and Kidney Transplantation Unit, Department of Translational Medicine (DIMET), University of Piemonte Orientale (UPO), "Maggiore della Carità" University Hospital, Novara, Italy.
Giuseppe CiancioloNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Paolo ContiNephro-Urological Department, AUSL "Toscana Sud Est", Italy.
Paolo FabbriniNephrology Unit, ASST Nord Milano, Ospedale Bassini, Cinisello Balsamo, Italy.
Carlo GiammarresiUnit of Nephrology, Dialysis and Kidney Transplant. Civico Hospital of Palermo, Palermo,  Italy.
Egidio ImbalzanoInternal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0003-2656-5467
Sandra La RosaNephrology and Dialysis Unit, "Giovanni Paolo II" Hospital, Sciacca, Italy.
Marita MarengoNephrology and Dialysis Unit, Department of Medical Specialties, ASLCN1, Cuneo, Italy.
Vincenzo MontinaroDivision of Nephrology and Dialysis, "Miulli" General Hospital Acquaviva delle Fonti, Italy.ORCID https://orcid.org/0000-0003-4018-0221
Dario MusoneDivision of Nephrology and Dialysis, Department of Medicine; Santa Maria Goretti Hospital, Latina, Italy.
Marcello NapoliNephrology Unit, Hospital V. Fazzi, Lecce, Italy.ORCID https://orcid.org/0000-0002-4535-4182
Felice NappiNephrology and Dialysis Unit, Hospital Santa Maria della Pietà, Nola, Italy.
Corrado PluvioNephrology Unit, AORN dei Colli, Naples, Italy.
Domenico SantoroNephrology and Dialysis Unit, Department of Clinic and Experimental Medicine, University of Messina, Messina, Italy.
Roberto ScarpioniNephrology and Dialysis Unit, "Guglielmo da Saliceto" Hospital, Piacenza, Italy.ORCID https://orcid.org/0000-0003-1809-0596
Franco SopranziNephrology and Dialysis Unit, County Hospital of Macerata, Macerata, Italy.
Tiziana TullioNephrology Unit, Hospital A. Fiorini, Terracina, Italy.
Luca De NicolaNephrology and Dialysis Unit, Department of Advanced Medical and Surgical Sciences, University of Campania, Naples, Italy.ORCID https://orcid.org/0000-0001-8532-0182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are recommended for reducing the renal and cardiovascular risk in patients with chronic kidney disease (CKD) based on the positive results reported by clinical trials. However, real-world data on the efficacy and the safety of these drugs in CKD population followed in nephrology setting are lacking. Methods: We report the effects of dapagliflozin in CKD patients by using data collected during a learning program in which 105 nephrologists added dapagliflozin (10 mg/day) to consecutive patients referred to their renal clinics. Efficacy endpoints were the albuminuria change and the determinants of an albuminuria decline ≥30%. Adverse events were also collected. Results: A total of 1724 patients with CKD (age 67.4 ± 13.2 years, 72.8% males, diabetes 59.9%, eGFR 43.5 ± 17.4 ml/min/1.73 m Conclusions: We provide evidence of the anti-proteinuric efficacy of short-term dapagliflozin in the presence of good safety profile in patients with CKD followed in nephrology.

Indexed as

albuminuriaCKDdapagliflozinreal worldSGLT2 inhibitors

Identifiers

PMID39834621
PMCPMC11744308

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.