ArticleIndian journal of clinical biochemistry : IJCB2025
Differential Impact of VNTR Polymorphism in the CBS Gene on Gastric and Breast Cancers Risk.
Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The cystathionine beta-synthase (CBS) gene plays a critical role in numerous physiological processes, including cellular proliferation, bioenergetics, and redox balance, and has been implicated in many cancers, including breast and gastric cancers. Previous studies have suggested that VNTR polymorphism in intron 13 of the CBS gene may influence enzyme activity, as an increase in the number of repeats in this VNTR leads to a reduction in the activity of the CBS enzyme. In this case-control study, for the first time, we genotyped 107 patients with gastric cancer (and 111 healthy controls) and 138 patients with breast cancer (and 124 healthy controls) for the CBS VNTR polymorphism using PCR. Our results showed that individuals with the 18/18 or 19/19 genotypes had a significantly higher risk of developing gastric cancer compared to those with the 17/17 genotype (OR = 2.14, 95% CI 1.12-4.09,
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