ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Extracellular Mitochondrial-Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
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Who cites it
34 citing papers in PubMed.
- Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances.Molecules (Basel, Switzerland) · 2026Review
- Mitochondrial micro-nano reactors via enhancing mitochondrial transfer and mitophagy for alleviating metabolic crisis.Bioactive materials · 2026Article
- Polysaccharide-engineered mitochondria reprogram macrophages to resolve diabetic wound inflammation and promote repair.Bioactive materials · 2026Article
- ROS-Responsive Eye Drop for Controlled Release of 20-Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Energetic metabolism-regulatory glycopeptide hydrogel accelerates pressure ulcer wound repair.Bioactive materials · 2026Article
- Artificial intelligence virtual extracellular vesicles (AIVEVs).Bioactive materials · 2026Review
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Integrated multi-technology exploration of the mechanism by which Badushengji San regulates core targets in diabetic foot ulcer.Molecular genetics and genomics : MGG · 2026Article
- Physical Exercise Counteracts Impaired Cognition by Improving Mitochondrial Function.International journal of molecular sciences · 2026Review
- hUCMSC mitochondrial EVs confer neuroprotection after ischemia by Tom1l2-mediated mitochondrial fusion and Crls1-cardiolipin axis reprogramming.Redox biology · 2026Article
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
- Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA.Bioactive materials · 2026Article
- Orchestrating diabetic wound repair via mitochondria-targeted delivery of dihydromyricetin with tailored ADSC-derived biohybrid nanovesicles.Materials today. Bio · 2026Article
- Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation.World journal of diabetes · 2026Article
- Dual-thermo-responsive microneedle patch for accelerated diabetic wound healing through on-demand drug release and active temperature management.Journal of nanobiotechnology · 2026Article
- Progress on hydrogel delivery systems targeting metabolism disorders in the treatment of diabetic foot ulcers.Frontiers in cell and developmental biology · 2026Review
- Targeting Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs): A Novel Therapeutic Strategy for Diabetic Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Glucose/ROS dual-responsive mitochondria-targeting nanozyme microneedles remodel mitochondrial homeostasis to orchestrate immune metabolic reprogramming for diabetic foot ulcer healing.Regenerative biomaterials · 2026Article
- Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies.Frontiers in pharmacology · 2026Review
- Prognostic value of blood glucose trajectories in critically ill patients with intracerebral hemorrhage: A retrospective cohort study.PloS one · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Huihui ZhangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zi YanGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Junyou ZhuDepartment of Burns, First affiliated hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Ziyue LiGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Lianglong ChenDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Weihan ZhengGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zhenning DaiDepartment of Stomatology, Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, 510095, China.
Jiaxin YangGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xinyi YunGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Yilin WangGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Hai ZhouDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Ziwei JiangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qiuyi YuDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Shiyu LiDepartment of Microbiology and Immunology, College of Basic Medicine and Public Hygiene, Jinan University, Guangzhou, 510632, China.ORCID https://orcid.org/0000-0002-2045-0012
Wenhua HuangGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Lei YangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Funding
China Postdoctoral Science Foundation 2021M701620Fundamental Research Funds for the Central Universities 21624220Guangdong Basic and Applied Basic Research Foundation 2020B1515120001Guangdong Basic and Applied Basic Research Foundation 2021A1515111074Guangdong Basic and Applied Basic Research Foundation 2023A1515012970Guangdong Basic and Applied Basic Research Foundation 2024A1515011230National Key R&D Program of China 2022YFB4600600National Natural Science Foundation of China 32271181National Natural Science Foundation of China 82102332National Natural Science Foundation of China 82300018National Natural Science Foundation of China 82302797National Natural Science Foundation of China 82372526Research Foundation of YunFu People's Hospital A20231001Science and Technology Innovation Project of Guangdong Province 2018KJYZ005Scientific research project of Traditional Chinese Medicine Bureau of Guangdong Province 20232007Yunfu Medical and Health Research Project 2022B004
Abstract
Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20)
Indexed as
Diabetic FootExtracellular VesiclesMitochondriaOxidative StressAnimalsApoptosisDiabetes Mellitus, ExperimentalDisease ProgressionHumansMaleMiceMice, Inbred C57BLWound Healingdiabetic foot ulcersextracellular vesiclesmitochondriamitochondrial‐derived vesiclesoxidative stress
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.