Evidence map›Paper›PMID 39835783›Full record

ArticleeLife2025

Paradoxical dominant negative activity of an immunodeficiency-associated activating

Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. The metabolically protective energy expenditure increase ofAmerican journal of physiology. Endocrinology and metabolism · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Patsy R TomlinsonThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
Rachel G KnoxThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
Olga PerisicMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Helen SuLaboratory of Clinical Immunology & Microbiology, Intramural Research Program, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, United States.
Gemma V BrierleyThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
Roger L WilliamsMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-7754-4207
Robert K SempleThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-6539-3069

Funding

Medical Research Council MC_U105184308Medical Research Council MC_UU_12012/5National Institute of Allergy and Infectious Diseases IntramuralWellcome TrustWellcome Trust 10.35802/102356Wellcome Trust 10.35802/210752
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Class Ia Phosphatidylinositol 3-KinaseGrowth DisordersImmunologic Deficiency SyndromesClass I Phosphatidylinositol 3-KinasesFibroblastsHumansHypercalcemiaMetabolic DiseasesMutationNephrocalcinosisPrimary Immunodeficiency DiseasesSignal TransductionClass Ia Phosphatidylinositol 3-KinaseClass I Phosphatidylinositol 3-KinasesPIK3R1 protein, humanAPDS2geneticsgenomicshumanimmunodeficiencyimmunologyinflammationinsulin resistancemousephosphoinositide 3-kinasePIK3R1SHORT syndrome

Identifiers

PMID39835783
PMCPMC11750134

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.