Evidence map›Paper›PMID 39836061›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.

Maya R Grayck, Bradford J Smith, Alexander Sosa, Emma Golden, William C McCarthy, Mack Solar, Natarajan Balasubramaniyan, Lijun Zheng, Evgenia Dobrinskikh, Mercedes Rincon and 3 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. TLR9-mediated innate immune signaling contributes to acetaminophen-induced injury in the developing lung.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  2. Review
  3. Article
  4. Don't Just Do Something, Stand There: Pressing Pause on Acetaminophen Use in Infants and Children.American journal of respiratory cell and molecular biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Maya R GrayckSection of Neonatology, Department of Pediatrics.
Bradford J SmithDepartment of Bioengineering and.
Alexander SosaDepartment of Bioengineering and.
Emma GoldenSection of Neonatology, Department of Pediatrics.
William C McCarthySection of Neonatology, Department of Pediatrics.
Mack SolarSection of Neonatology, Department of Pediatrics.
Natarajan BalasubramaniyanSection of Neonatology, Department of Pediatrics.
Lijun ZhengSection of Neonatology, Department of Pediatrics.
Evgenia DobrinskikhSection of Neonatology, Department of Pediatrics.
Mercedes RinconDepartment of Immunology and Microbiology, and.
David J McCulleyDivision of Neonatology, Department of Pediatrics, University of California, San Diego, San Diego, California.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz School of Medicine, Aurora, Colorado.
Clyde J WrightSection of Neonatology, Department of Pediatrics.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Research Supplement to Promote Diversity in Health Related Research: Pulmonary implications ofperinatal acetaminophen exposureR01HD107700 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Clyde Jason Wright · 2022 to 2026
$2.2M
NICHD NIH HHS R01 HD107700NIDDK NIH HHS P30 DK048520NIH HHS R01HD107700
6 · The paper itself

Abstract

Whether early-life acetaminophen (APAP) exposures injure the developing lung is controversial. We sought to correlate murine pulmonary developmental expression profiles of

Indexed as

AcetaminophenLungAnimalsCytochrome P-450 CYP2E1Interleukin-6MiceMice, Inbred C57BLMice, KnockoutMitochondriaNF-E2-Related Factor 2Signal TransductionSTAT3 Transcription FactorAcetaminophenCytochrome P-450 CYP2E1Interleukin-6interleukin-6, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Stat3 protein, mouseSTAT3 Transcription FactoracetaminophenCyp2e1Il6lung injuryparacetamol

Identifiers

PMID39836061
PMCPMC12334886

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.