ArticleClinical oral investigations2025
Clinical and imaging aspects associated with persistent apical periodontitis: subsides for the treatment decision-making process.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Three-Year Apical Outcomes in Teeth with Apical Periodontitis Following Primary Endodontic Treatment or Nonsurgical Retreatment: A Retrospective Clinical Study.Journal of clinical medicine · 2026Article
- YoLeTooth: A Unified Framework for Joint Tooth Segmentation and Periapical Lesion Detection in Panoramic Radiographs.Journal of imaging · 2026Article
- Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research.International endodontic journal · 2026Article
- A novel full digital workflow for dental autotransplantation: surgical accuracy and clinical outcomes in a prospective cohort study.Frontiers in oral health · 2026Article
- mRNA expression of DNA methylation machinery genes in periapical granuloma and their potential relationship with periapical wound healing.Scientific reports · 2025Article
- Effect of membrane vesicles produced under different pH conditions on the ability ofJournal of bacteriology · 2025Article
- Genetic Analysis ofGenes · 2025Article
- Advances in clinical and translational research in endodontics: A comprehensive overview.Brazilian dental journal · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo evaluate cases of persistent apical periodontitis (PAP) and what are the imaging and clinical aspects that could be considered in the PAP diagnosis and in their treatment decision-making process. METHODOLOGY: 423 patients with apical periodontitis at the time of non-surgical root canal treatment (NSRCT) were followed-up for at least 1 year. Periapical radiographic images were used to compare and determine periapical status at each time using the PAI scoring system. Cases scored as PAI 5 at the follow-up appointment were evaluated by CBCT, using the CBCTPAI scoring system. Associated, the data from imaging exams and from clinical evaluation were considered to make a decision for PAP treatment.
resultsRegarding sample composition, it was observed an association with ethnicity and PAP (p = 0.045). After follow-up, cases classified as PAI Score 1 and 2 and absence of symptoms/complaint were classified as successful. Cases classified as PAI Score 3 and absence of symptoms/complaint were referred for new follow-up visits until complete resolution of PAP. Cases scored as PAI 4 with clinical symptoms were indicated for non-surgical root canal retreatment. Cases scored as PAI 5 were assessed by CBCT, and in the presence of symptoms/complaint and a CBCTPAI score 3 were related to non-surgical root canal retreatment, while CBCTPAI scores 4 and 5 were refereed for endodontic surgery.
conclusionsClinical data, PAI and CBCTPAI scoring systems from image exams can be useful for PAP diagnosis and their treatment. CLINICAL RELEVANCE: In the decision-making process, clinical and imaging data are fundamental for the choose of an ideal protocol for treating PAP.
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Registered trials
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