Evidence map›Paper›PMID 39838061›Full record

ArticleScientific reports2025

Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis.

Takahiro Imaizumi, Takeshi Hasegawa, Takaaki Kosugi, Hiroki Nishiwaki, Masanori Abe, Norio Hanafusa, Hirokazu Honda, Kazuhiko Tsuruya, Yasuhiko Ito, Takahiro Kuragano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takahiro ImaizumiDepartment of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan. imaizumi.takahiro.r7@f.mail.nagoya-u.ac.jp.
Takeshi HasegawaInstitute of Clinical Epidemiology, Showa University, Tokyo, Japan.
Takaaki KosugiDepartment of Nephrology, Nara Medical University, Kashihara, Nara, Japan.
Hiroki NishiwakiDivision of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Masanori AbeDivision of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Norio HanafusaCommittee of the Japanese Society for Dialysis Therapy Renal Data Registry, the Japanese Society for Dialysis Therapy, Tokyo, Japan.
Hirokazu HondaDivision of Nephrology, Department of Medicine, School of Medicine, Showa University, Tokyo, Japan.
Kazuhiko TsuruyaDepartment of Nephrology, Nara Medical University, Kashihara, Nara, Japan.
Yasuhiko ItoDepartment of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan.
Takahiro KuraganoDivision of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Funding

Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 24K06239
6 · The paper itself

Abstract

Preservation of residual kidney function (RKF) is important in patients undergoing peritoneal dialysis (PD). We aimed to examine the association between anemia management and residual urine output using data from a nationwide survey of dialysis patients. After excluding patients with anuria at baseline from the Total cohort of 2,712, 659 of 1,640 patients developed anuria during a median follow-up of 2.5 (interquartile range: 1.5-4.2) years. Urine volume decreased more rapidly as hemoglobin decreased or as the erythropoiesis-stimulating agent (ESA) resistance index (ERI) increased. The hazard ratios with 95% confidence intervals for the development of anuria, defined as residual urine volume ≤ 100 mL/day, were 1.65 (1.20-2.27), 1.39 (1.08-1.77), and 1.32 (1.07-1.63) for hemoglobin levels of < 9.0, 9.0-9.9, and 10.0-10.9 g/dL compared with 11.0-11.9 g/dL, and 1.35 (1.10-1.66) and 1.41 (1.14-1.73) for the second and third tertiles of ERI compared with the first tertile. In conclusion, patients with a low hemoglobin level or a high ERI were more likely to experience a decline in residual urine output and to develop anuria. Further studies are needed to investigate the effects of interventions that could improve renal anemia and/or ESA hyporesponsiveness on RKF preservation.

Indexed as

AnemiaHematinicsKidneyPeritoneal DialysisAdultAgedFemaleHemoglobinsHumansMaleMiddle AgedHematinicsHemoglobinsAnuriaErythropoiesis-stimulating agent resistance indexHyporesponsiveness to erythropoiesis-stimulating agentPeritoneal dialysisResidual kidney function

Identifiers

PMID39838061
PMCPMC11751488

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.