Evidence map›Paper›PMID 39838262›Full record

ArticleGut microbes2025

Stevioside mitigates metabolic dysregulation in offspring induced by maternal high-fat diet: the role of gut microbiota-driven thermogenesis.

Jin Ye, Renjie Shi, Xiaoning Wu, Hua Fan, Yapei Zhao, Xinyun Hu, Lulu Wang, Xiaowei Bo, Dongning Li, Yunshu Ge and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ALDH1L1 reverses CD8Journal of translational medicine · 2026
    Article
  2. The progress on stevia (Frontiers in nutrition · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jin YeCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Renjie ShiCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Xiaoning WuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Hua FanCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yapei ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Xinyun HuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Lulu WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Xiaowei BoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Dongning LiCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yunshu GeCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Danna WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Bing XiaCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Zhenting ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Chunxia XiaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Beita ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yutang WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Xuebo LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal obesity poses a significant threat to the metabolic profiles of offspring. Microorganisms acquired from the mother early in life critically affect the host's metabolic functions. Natural non-nutritive sweeteners, particularly stevioside (STV), play a crucial role in reducing obesity and affecting gut microbiota composition. Based on this, we hypothesized that maternal STV supplementation could improve the health of mothers and offspring by altering their gut microbiota. Our study found that maternal STV supplementation reduced obesity during pregnancy, decreased abnormal lipid accumulation in offspring mice caused by maternal obesity, and modified the gut microbiota of both dams and offspring, notably increasing the abundance of

Indexed as

Diterpenes, KauraneGastrointestinal MicrobiomeGlucosidesPrenatal Exposure Delayed EffectsThermogenesisAnimalsDietary SupplementsDiet, High-FatFemaleLactobacillusLipid MetabolismMaleMiceMice, Inbred C57BLObesityPregnancyDiterpenes, KauraneGlucosidessteviosidegut microbiotamaternal obesityoffspring lipid metabolic disordersStevioside

Identifiers

PMID39838262
PMCPMC12716059

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.