Evidence map›Paper›PMID 39838520›Full record

ArticleThe FEBS journal2025

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism.

Aenne-Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia-Marcos and 2 more

Abstract read
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. International journal of molecular sciences · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mechanisms Involved in Pathological Succinate-Mediated Signaling.International journal of molecular sciences · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aenne-Dorothea LiebingRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Philipp RabeRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Petra KrumbholzRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Christian ZieschangRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Franziska BischofRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Angela SchulzRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Susan BilligResearch Group of Mass Spectrometry, Institute of Analytical Chemistry, Leipzig University, Germany.
Claudia BirkemeyerResearch Group of Mass Spectrometry, Institute of Analytical Chemistry, Leipzig University, Germany.
Thanigaimalai PillaiyarInstitute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Germany.
Mikel Garcia-MarcosDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, MA, USA.
Robert KraftCarl Ludwig Institute for Physiology, Medical Faculty, Leipzig University, Germany.
Claudia StäubertRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.ORCID 0000-0003-0721-8507

Funding

Addressing the complexity and plasticity of heterotrimeric G protein signalingR35GM156286 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Mikel Garcia-Marcos · 2025 to 2026
$1.4M
Deutsche Forschungsgemeinschaft 407707190Deutsche Forschungsgemeinschaft 421152132Deutsche Forschungsgemeinschaft SFB1423NIGMS NIH HHS R35 GM156286NIH HHS R35GM156286Universität Leipzig Pre-Doc Award
6 · The paper itself

Abstract

Succinate is a pivotal tricarboxylic acid cycle metabolite but also specifically activates the G

Indexed as

Receptors, G-Protein-CoupledSuccinic AcidCalciumCell MembraneGlucoseGlutamineHEK293 CellsHumansOxidative PhosphorylationSignal TransductionCalciumGlucoseGlutamineReceptors, G-Protein-CoupledSuccinic AcidSUCNR1 protein, humanmacrophagesmetabolismsignal transductionsuccinateSUCNR1

Identifiers

PMID39838520
PMCPMC12001207

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.