Evidence map›Paper›PMID 39839588›Full record

ArticleFrontiers in child and adolescent psychiatry2023

Investigating heterogeneity across autism, ADHD, and typical development using measures of cortical thickness, surface area, cortical/subcortical volume, and structural covariance.

Younes Sadat-Nejad, Marlee M Vandewouw, R Cardy, J Lerch, M J Taylor, A Iaboni, C Hammill, B Syed, J A Brian, E Kelley and 7 more

Abstract read
In one paragraph

Article in Frontiers in child and adolescent psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Younes Sadat-NejadAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Marlee M VandewouwAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
R CardyAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
J LerchMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
M J TaylorDiagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
A IaboniAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
C HammillMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
B SyedMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
J A BrianAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
E KelleyDepartment of Psychology, Queen's University, Kingston, ON, Canada.
M AyubDepartment of Psychiatry, Queen's University, Kingston, ON, Canada.
J CrosbieDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
R SchacharDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
S GeorgiadesDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
R NicolsonDepartment of Psychiatry, Western University, London, ON, Canada.
E AnagnostouAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
A KushkiAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism are multi-faceted neurodevelopmental conditions with limited biological markers. The clinical diagnoses of autism and ADHD are based on behavioural assessments and may not predict long-term outcomes or response to interventions and supports. To address this gap, data-driven methods can be used to discover groups of individuals with shared biological patterns. Methods: In this study, we investigated measures derived from cortical/subcortical volume, surface area, cortical thickness, and structural covariance investigated of 565 participants with diagnoses of autism [ Results: Our findings suggest two large clusters, which differed in measures of adaptive functioning ( Discussion: These clusters did not align with existing diagnostic labels, suggesting that brain structure is more likely to be associated with differences in adaptive functioning, IQ, and ADHD features.

Indexed as

ADHDautismbrain structureclusteringdata drivenneurodevelopmental conditions

Identifiers

PMID39839588
PMCPMC11747914

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.