Evidence map›Paper›PMID 39839763›Full record

ArticleFrontiers in oncology2024

BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center's experience.

S S McThenia, K M Reddy, E Damaraju, E Castellino, Z He, R Beers, F Chien, R C Castellino, A E Goldman-Yassen, J R Fangusaro and 1 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pediatric low-grade brainstem glioma: a review of current diagnosis and treatment paradigms in the molecular era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S S McTheniaDepartment of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.
K M ReddyDepartment of Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States.
E DamarajuDepartment of Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States.
E CastellinoDepartment of Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Z HeDepartment of Pediatrics, Emory University, Atlanta, GA, United States.
R BeersDepartment of Pediatrics, Emory University, Atlanta, GA, United States.
F ChienDepartment of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.
R C CastellinoDepartment of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.
A E Goldman-YassenDepartment of Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States.
J R FangusaroDepartment of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.
T MacDonaldDepartment of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pediatric low-grade gliomas (pLGGs) have an overall survival of over 90%; however, patients harboring a BRAF Methods: A single institution retrospective chart review analysis was performed on patients, 0 to 21 years of age, with newly diagnosed and/or progressive BRAF Results: Fifteen patients diagnosed with BRAF Discussion: In this small cohort of incompletely resected BRAF

Indexed as

BRAF inhibitorBRAFV600E-mutationCNS tumorsdabrafenibmonotherapyoutcomespLGG

Identifiers

PMID39839763
PMCPMC11747024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.