ArticlePsychoradiology2024
Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy.
Article in Psychoradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex Vivo Imaging Validated With Histology.Hippocampus · 2026Article
- Mapping neurophysiological biotypes of postpartum depression and underlying neural and molecular basis.Communications medicine · 2026Article
- Neurobiological mechanisms of electroconvulsive therapy in major depressive disorder: structure-function coupling with gene expression and molecular mechanism.Translational psychiatry · 2026Article
- Personalized functional network connectivity abnormalities in chronic insomnia disorder.Psychoradiology · 2026Article
- Subtyping insomnia disorder with a population graph attention autoencoder: revealing two distinct biotypes.Frontiers in neuroscience · 2026Article
- Functional Connectivity Changes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Graph-Theoretic and Topology-Based Study.Brain and behavior · 2025Article
- Aberrant functional connectivity and the intrinsic activity of primary visual network and their relationship with adolescent atypical depression symptoms.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Background: The hippocampus has been widely reported to be involved in the neuropathology of major depressive disorder (MDD). All the previous researches adopted group-level hippocampus subregions atlas to investigate abnormal functional connectivities in MDD in absence of capturing individual variability. In addition, the molecular basis of functional impairments of hippocampal subregions in MDD remains elusive. Objective: We aimed to reveal functional disruptions and recovery of individual hippocampal subregions in MDD patients before and after ECT and linked these functional connectivity differences to transcriptomic profiles to reveal molecular mechanism. Methods: we used group guided individual functional parcellation approach to define individual subregions of hippocampus for each participant. Resting-state functional connectivity (FC) analysis of individual hippocampal subregions was conducted to investigate functional disruptions and recovery in MDD patients before and after ECT. Spatial association between functional connectivity differences and transcriptomic profiles was employed to reveal molecular mechanism. Results: MDD patients showed increased FCs of the left tail part of hippocampus with dorsolateral prefrontal cortex and middle temporal gyrus while decreased FC with primary visual cortex. These abnormal FCs in MDD patients were normalized after ECT. In addition, we found that functional disruptions of the left tail part of hippocampus in MDD were mainly related to synaptic signaling and transmission, ion transport, cell-cell signaling and neurogenesis. Conclusion: Our findings provide initial evidence for functional connectome disruption of individual hippocampal subregions and their molecular basis in MDD.
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