ReviewFrontiers in neuroscience2024
Olfactory dysfunction as potential biomarker in neurodegenerative diseases: a narrative review.
Review in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Article
- Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population-Based Rhineland Study.International forum of allergy & rhinology · 2026Article
- Review
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.Cell regeneration (London, England) · 2026Review
- Article
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- The olfactory-glymphatic syndrome: linking smell dysfunction, cognitive impairment and sleep disturbances in neuropathological disorders.Frontiers in neuroscience · 2026Review
- Olfactory impairment in Huntington's disease: A systematic review and meta-analysis.Neuroscience applied · 2026Article
- Olfactory Dysfunction and Cognitive Decline: Are They Related?Current allergy and asthma reports · 2025Review
- Altered Prefrontal Dynamic Functional Connectivity in Vascular Dementia During Olfactory Stimulation: An fNIRS Study.Bioengineering (Basel, Switzerland) · 2025Article
- Optical coherence tomography - A possible biomarker in early huntington's disease.Neurological research and practice · 2025Article
- Olfactory Network Functional Connectivity as a Marker for Parkinson's Disease Severity.Life (Basel, Switzerland) · 2025Article
- Olfactory GPCRs through the lens of structural bioinformatics.Chemical senses · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative diseases represent a group of disorders characterized by progressive degeneration of neurons in the central nervous system, leading to a range of cognitive, motor, and sensory impairments. In recent years, there has been growing interest in the association between neurodegenerative diseases and olfactory dysfunction (OD). Characterized by a decline in the ability to detect or identify odors, OD has been observed in various conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS). This phenomenon often precedes the onset of other clinical symptoms, suggesting its potential utility as an early marker or prodromal symptom of neurodegenerative diseases. This review provides a vast literature overview on the current knowledge of OD in PD, AD, ALS, and HD in order to evaluate its potential as a biomarker, particularly in the early and prodromal stages of these diseases. We summarize the most common methods used to measure olfactory function and delve into neuropathological correlations and the alterations in neurotransmitter systems associated with OD in those neurodegenerative diseases, including differences in genetic variants if applicable, and cater to current pitfalls and shortcomings in the research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.