Evidence map›Paper›PMID 39840157›Full record

ArticleCureus2024

Racial Disparities in Cardiometabolic Disorders Among Alzheimer's Disease Patients: A Study on Native Hawaiians and Pacific Islanders.

Justin H Wong, Anna Gan, Lauren Nguyen, Lea Zoe El-Hage, Keao Kawaakoa, Meliza Roman, Chathura Siriwardhana, Enrique Carrazana, Kore K Liow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justin H WongDepartment of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Anna GanDepartment of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Lauren NguyenDepartment of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Lea Zoe El-HageDepartment of Neuroscience, Middlesex University, London, GBR.
Keao KawaakoaDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, USA.
Meliza RomanDepartment of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Chathura SiriwardhanaDepartment of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Enrique CarrazanaDepartment of Neurology, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Kore K LiowDepartment of Neurology, Hawaii Pacific Neuroscience, Honolulu, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiometabolic disorders may accelerate the progression of Alzheimer's disease (AD), potentially impacting ethnic-racial groups with a higher prevalence of diabetes, obesity, and cardiovascular disease, though limited data exists on Native Hawaiians and Pacific Islanders (NHPI) populations.

objectiveThis study aims to examine the prevalence of diabetes and associated comorbidities among AD patients from different ethnic-racial groups - Asians, Whites, and NHPIs - in Hawaii, with a focus on identifying risk factors linked to AD.

methodA retrospective review was conducted on AD patient records from a single center in Hawaii, spanning June 2018 to June 2024. Variables assessed included age at diagnosis, sex, race, insurance type, alcohol use, comorbidities, and Mini-Mental State Examination (MMSE) scores. Statistical comparisons were conducted to identify group differences.

resultsAmong 540 patients (256 Asians, 89 NHPIs, 182 Whites, and 13 Others), NHPIs exhibited the highest rates of hypertension (66.3%), diabetes (31.5%), obesity (23.6%), congestive heart failure (13.5%), and coronary artery disease (6.7%). Whites exhibited a higher prevalence of anxiety (18.1%), cardiac arrhythmia (15.4%), and alcohol use (37.4%) compared to Asians and NHPIs. Females had lower mean MMSE scores compared to males (18.3 ± 7.4 vs. 21.0 ± 6.2, respectively), along with higher rates of anxiety (16.3%), hypertension (62.2%), hyperlipidemia (47.4%), and underweight body mass index (10.8%).

conclusionNHPI AD patients in Hawaii face a higher prevalence of diabetes and a greater burden of cardiometabolic disorders compared to other racial groups. White AD patients demonstrate higher rates of anxiety, alcohol consumption, and cardiac arrhythmia compared to Asians and NHPIs. Females with AD had worse cognitive function compared to males.

Indexed as

alzheimer diseasecardiometabolic disorderdiabetesnative hawaiianpacific islander

Identifiers

PMID39840157
PMCPMC11750210

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.