Evidence map›Paper›PMID 39840995›Full record

ArticlemSystems2025

The combination of

Dengxiong Hua, Qin Yang, Xiaowei Li, Xuexue Zhou, Yingqian Kang, Yan Zhao, Daoyan Wu, Zhengrong Zhang, Boyan Li, Xinxin Wang and 4 more

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Synergistic effects ofmSystems · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Frontiers in microbiology · 2026
    Article
  13. Recent advances in the positive role ofFrontiers in immunology · 2026
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dengxiong Hua *Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.ORCID 0000-0002-7036-1827
Qin Yang *Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Xiaowei Li *Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Xuexue ZhouKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Yingqian KangKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.ORCID 0009-0005-6033-447X
Yan ZhaoKey Laboratory of Endemic and Ethnic Diseases, Ministry of Education & School/Hospital of Stomatology Guizhou Medical University, Guiyang, Guizhou, China.
Daoyan WuKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Zhengrong ZhangKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Boyan LiSchool of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.
Xinxin WangKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.
Xiaolan QiKey Laboratory of Endemic and Ethnic Diseases, Ministry of Education & School/Hospital of Stomatology Guizhou Medical University, Guiyang, Guizhou, China.ORCID 0000-0002-9108-6772
Zhenghong ChenKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.ORCID 0000-0002-2944-6001
Guzhen CuiKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.ORCID 0000-0002-6500-039X
Wei HongKey Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical University, Guiyang, China.ORCID 0000-0002-3317-9401

Funding

111 Program (D20009)Excellent Young Talents Plan of Guizhou Medical University (2022)101Guizhou province high-level innovation talent team and talent baseproject (GCC[2022] 036-1)Guizhou Provincical Key Laboratory of Pathogen Biology (QJJ [2022] 019)Innovation and Entrepreneurship project for overseas talents in Guizhou (2022-08)International sciencesn and technology cooperation base of Guizhou ([2020]4101)MOST | National Natural Science Foundation of China (NSFC) 32160015,32170134,32460046
6 · The paper itself

Abstract

The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as IMPORTANCE: Our study suggests that the combined administration of CB and AKK probiotics, as opposed to a single probiotic strain, holds considerable promise in preventing the advancement of IBD to CRC. This synergistic effect is attributed to the ability of this probiotic combination to more effectively modulate the gut microbiota, curb inflammatory reactions, bolster the efficacy of immunotherapeutic approaches, and optimize treatment results via fecal microbiota transplantation.

Indexed as

CD8-Positive T-LymphocytesClostridium butyricumColitisGastrointestinal MicrobiomeProbioticsAkkermansiaAnimalsCarcinogenesisColorectal NeoplasmsDextran SulfateDisease Models, AnimalMaleMiceMice, Inbred C57BLDextran SulfateAkkermansia muciniphilaClostridium butyricumcolitis-associated colorectal cancerinflammatory bowel diseaseprobiotic bacteria

Identifiers

PMID39840995
PMCPMC11834468

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.