ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Modulatory Neurotransmitter Genotypes Shape Dynamic Functional Connectome Reconfigurations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Early warning indicator system for adolescent student mental health: theoretical construction of the relationship-belief-process-state model.Frontiers in psychology · 2026Review
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Dynamic reconfigurations of the functional connectome across different connectivity states are highly heritable, predictive of cognitive abilities, and linked to mental health. Despite their established heritability, the specific polymorphisms that shape connectome dynamics are largely unknown. Given the widespread regulatory impact of modulatory neurotransmitters on functional connectivity, we comprehensively investigated a large set of single nucleotide polymorphisms (SNPs) of their receptors, metabolic enzymes, and transporters in 674 healthy adult subjects (347 females) from the Human Connectome Project. Preregistered modulatory neurotransmitter SNPs and dynamic connectome features entered a Stability Selection procedure with resampling. We found that specific subsets of these SNPs explain individual differences in temporal phenotypes of fMRI-derived connectome dynamics for which we previously established heritability. Specifically, noradrenergic polymorphisms explained Fractional Occupancy, i.e., the proportion of time spent in each connectome state, and cholinergic polymorphisms explained Transition Probability, i.e., the probability to transition between state pairs, respectively. This work identifies specific genetic effects on connectome dynamics via the regulatory impact of modulatory neurotransmitter systems. Our observations highlight the potential of dynamic connectome features as endophenotypes for neurotransmitter-focused precision psychiatry.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.