Evidence map›Paper›PMID 39843732›Full record

ArticleGeroScience2025

Blockade of A

Mariana Sayuri Berto Udo, Julia Zaccarelli-Magalhães, Garrett Alan Clemons, Cristiane Teresinha Citadin, Julia Langman, Drew James Smith, Luiz Henrique Matuguma, Vesna Tesic, Hung Wen Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariana Sayuri Berto UdoDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Julia Zaccarelli-MagalhãesDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Garrett Alan ClemonsDepartment of Biomedical Science, West Virginia School of Osteopathic Medicine, Lewisburg, WV, USA.
Cristiane Teresinha CitadinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Julia LangmanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Drew James SmithDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Luiz Henrique MatugumaDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Vesna TesicDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Hung Wen LinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA. kevin.lin.1@uth.tmc.edu.ORCID 0000-0003-1010-5423

Funding

Protein Arginine Methyltransferases in Alzheimer's diseaseR01AG081258 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2025 to 2025
$754k
Using Photobiomodulation to Alleviate Brain Hypoperfusion in Alzheimer's DiseaseR01AG081874 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2025 to 2025
$582k
American Heart Association 22TPA970253American Heart Association 23CDA1051814American Heart Association 23POST1018945NIA NIH HHS R01 AG081258NIA NIH HHS R01 AG081874NIH HHS 1R01AG081258-01A1NIH HHS 1R01AG081874-01NIH HHS 1RF1NS132291-01NINDS NIH HHS RF1 NS132291
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than 6.2 million Americans aged 65 and older, particularly women. Along with AD's main hallmarks (formation of β-amyloid plaques and tau neurofibrillary tangles), there are vascular alterations that occurs in AD pathology. Adenosine A2 receptor (A

Indexed as

Adenosine A2 Receptor AntagonistsAlzheimer DiseaseBrainCerebrovascular CirculationCognitionPurinesReceptor, Adenosine A2AAnimalsBlood-Brain BarrierDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicProtein-Arginine N-MethyltransferasesAdenosine A2 Receptor AntagonistsistradefyllineProtein-Arginine N-MethyltransferasesPurinesReceptor, Adenosine A2AAdenosine A2 ReceptorAlzheimer's DiseaseBrain PerfusionProtein Arginine Methyltransferase 4

Identifiers

PMID39843732
PMCPMC12181614

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.