Evidence map›Paper›PMID 39843801›Full record

ArticleNature cardiovascular research2025

Mitochondrial NAD

Jingjing Zhang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Wenrui Ma, Shaowen Liu, Yixuan Fang, Shufen Zheng, Ce Huang, Guoquan Yan and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Hepatocyte mitochondrial NADNature metabolism · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. TRPM7 channel as a potential therapeutic target for AAA.Nature cardiovascular research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jingjing Zhang *Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0004-0099-1008
Yuyi Tang *Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shan Zhang *Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zhuxin Xie *Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wenrui Ma *Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shaowen LiuShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yixuan FangShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shufen ZhengGreater Bay Area Institute of Precision Medicine, School of Life Sciences, Fudan University, Shanghai, China.
Ce HuangShanghai Institute of Infectious Disease and Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China.
Guoquan YanShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Mieradilijiang AbudupataerDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yue XinShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Jingqiao ZhuShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wenjing HanShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Weizhong WangShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Fenglin ShenShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Hao LaiDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yang LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Dan YeShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Fa-Xing YuShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-4834-9335
Yanhui XuShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Cuiping PanGreater Bay Area Institute of Precision Medicine, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-8152-2489
Chunsheng WangDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Kai ZhuDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. zhu.kai1@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-2391-4193
Weijia ZhangShanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. weijiazhang@fudan.edu.cn.ORCID http://orcid.org/0000-0001-6928-0416

Funding

National Natural Science Foundation of China (National Science Foundation of China) 51927805National Natural Science Foundation of China (National Science Foundation of China) 82070482National Natural Science Foundation of China (National Science Foundation of China) 82370472Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 2017SHZDZX01
6 · The paper itself

Abstract

Thoracic and abdominal aortic aneurysm poses a substantial mortality risk in adults, yet many of its underlying factors remain unidentified. Here, we identify mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ deficiency as a causal factor for the development of aortic aneurysm. Multiomics analysis of 150 surgical aortic specimens indicated impaired NAD

Indexed as

Aortic Aneurysm, AbdominalAortic Aneurysm, ThoracicAortic DissectionCollagen Type IIIMitochondria, MuscleMuscle, Smooth, VascularNADAnimalsCytokinesDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutCollagen Type IIICytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, human

Identifiers

PMID39843801

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.