Evidence mapPaperPMID 39844019Full record

ArticleAddiction (Abingdon, England)2025

Nationwide trends in diagnosed sedative, hypnotic or anxiolytic use disorders in adolescents and young adults enrolled in Medicaid: 2001-2019.

Greta Bushnell, Kristen Lloyd, Mark Olfson, Tobias Gerhard, Katherine Keyes, Magdalena Cerdá, Deborah Hasin

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Sedative and Anxiolytic Activities ofVeterinary medicine international · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Greta BushnellCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, USA.ORCID https://orcid.org/0000-0002-4056-8405
Kristen LloydCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, USA.
Mark OlfsonDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Tobias GerhardCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, USA.
Katherine KeyesDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Magdalena CerdáCenter for Opioid Epidemiology and Policy, Department of Population Health, New York University School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0001-8441-7046
Deborah HasinDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID https://orcid.org/0000-0002-6533-7021

Funding

Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribingK01DA050769 · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2025 to 2025
$196k
NIDA NIH HHS K01 DA050769NIDA NIH HHS K01DA050769
6 · The paper itself

Abstract

BACKGROUND AND

aimSedative, hypnotic or anxiolytic use disorders (SHA-UD) are defined by significant impairment or distress caused by recurrent sedative, hypnotic or anxiolytic use. This study aimed to measure trends in the prevalence of SHA-UD diagnoses in adolescent and young adult US Medicaid enrollees from 2001 to 2019.

designAnnual, cross-sectional study, 2001-2019.

settingMedicaid Analytic eXtracts (MAX) and Transformed Medicaid Analytic Files (TAF) from 42 US states with complete data. PARTICIPANTS/CASES: Adolescents (13-17 years) and young adults (18-29 years) with ≥10 months Medicaid enrollment in the calendar year; analytic sample contained 5.7 (2001) to 13.2 (2019) million persons per year. MEASUREMENTS: Annual prevalence of SHA-UD in adolescent and young adult Medicaid enrollees [defined as an inpatient or outpatient ICD code (304.1x, 305.4x, F13.1x, F13.2x) in the calendar year] was stratified by sex, race/ethnicity, receipt of a benzodiazepine, z-hypnotic or barbiturate prescription, and selected mental health diagnoses. Absolute and relative percent-changes from 2001 vs. 2019 were summarized. Secondary analyses were restricted to states with more consistent data capture.

findingsThe prevalence of SHA-UD diagnoses statistically significantly increased for adolescents (0.01% to 0.04%) and young adults (0.05% to 0.24%) from 2001 to 2019. Increasing trends were observed in sex and race/ethnicity subgroups, with greatest relative increases among Non-Hispanic Black (624%) and Hispanic (529%) young adults. The trend increased among those with and without a benzodiazepine, z-hypnotic or barbiturate prescription; i.e. young adults with (2001 = 0.39% to 2019 = 1.77%) and without (2001 = 0.03% to 2019 = 0.18%) a prescription. Most adolescents (76%) and young adults (91%) with a SHA-UD diagnosis in 2019 had a comorbid substance use disorder.

conclusionsSedative, hypnotic or anxiolytic use disorders (SHA-UD) diagnoses increased 3- to 5-fold between 2001 and 2019 for adolescent and young adult US Medicaid enrollees, with prevalence remaining low in adolescents. The increase over two decades may be attributed to changes in the availability, use and misuse of sedative, hypnotic and anxiolytic medications and to increased detection, awareness and diagnosing of SHA-UD.

Indexed as

Anti-Anxiety AgentsHypnotics and SedativesMedicaidSubstance-Related DisordersAdolescentAdultCross-Sectional StudiesFemaleHumansMalePrevalenceUnited StatesYoung AdultAnti-Anxiety AgentsHypnotics and Sedativesadolescentanti‐anxiety agentsbenzodiazepinehypnotics and anxiolytic use disorderhypnotics and sedativessedativesubstance‐related disordersyoung adult

Identifiers

PMID39844019
PMCPMC11986281

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.