ArticleBMC gastroenterology2025
Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007-2010.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Associations between psychological distress and thyroid cancer, and the mediating role of lifestyle and metabolism: a cohort study from the UK Biobank.Frontiers in oncology · 2026Article
- Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026Review
- Association of C-reactive protein-triglyceride glucose index with anxiety in American adults: outcomes from NHANES 2007 to 2010.European journal of medical research · 2025Article
- An Association Analysis of Anxiety and Psoriasis: Based on the NHANES Database.Brain and behavior · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundConstipated patients may exhibit anxious behaviors, but the relationship between the two remains unclear. This population-based study aims to investigate the relationships of anxiety status and anxiety duration with constipation among U.S. adults.
methodsUsing data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study included 8945 participants was performed to assess the relationships of anxiety status and anxiety duration with constipation. Participants' characteristics were presented using mean or proportion. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression models. The analysis accounted for potential confounding factors, including gender, age, race/ethnicity, education level, marital status, PIR, BMI, smoking status, drinking status, chronic diseases, and dietary intake. Subgroup analyses were conducted to ensure the stability of the results. Smoothed curve fitting was applied to investigate both linear and nonlinear associations between anxiety duration and constipation risk. Threshold effects were assessed using two-piecewise linear regression models.
resultsOf the 8945 participants, 922 reported constipation, with a prevalence of 10.3%. After adjusting for confounding factors, individuals with anxiety status exhibited an increased risk of constipation (OR: 1.49, 95% CI: 1.28-1.73). Stratified analyses indicated that the association between anxiety status and constipation remained relatively stable across different stratification levels. Smoothed curve fitting and threshold effect analyses revealed a linear association between anxiety duration and constipation among adults aged 20-60, while a nonlinear inverted U-shaped relationship was observed in those aged 60 and older, with an inflection point at 10 days. The two variables correlated positively on the left side of the inflection point but not on the right.
conclusionThis study showed that a significant association between anxiety status and constipation among U.S. adults. Additionally, an age-dependent association between anxiety duration and constipation was observed, particularly among individuals aged 60 and older.
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