ArticleBMC gastroenterology2025
The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007-2010.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES.BMC pulmonary medicine · 2025Article
- Association between dietary index for gut microbiota and diarrhea among US adults: a cross-sectional analysis of NHANES 2005-2010.Frontiers in nutrition · 2025Article
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Abstract
backgroundOxidative stress is associated with functional bowel disorders. The Oxidative Balance Score (OBS) is used to represent the overall level of oxidative stress experienced by an individual. Sex differences are exhibited in the occurrence of constipation and diarrhea. This population-based study aimed to examine the association between the OBS, constipation, and diarrhea, among adults in the United States (US), stratified by sex.
methodsUsing data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study including 4,462 participants (2,386 males and 2,076 females) was performed to assess the relationship between the OBS, constipation, and diarrhea, among adult men and women in the US. Constipation and diarrhea were identified according to bowel frequency and stool type, as outlined in the Bowel Health Questionnaire. The independent variable was the OBS based on 20 types of dietary and lifestyle components. We conducted a binary logistic regression subgroup analysis by sex, and a univariate subgroup analysis; and used a restricted cubic spline (RCS) to illustrate the relationship between the OBS and abnormal bowel health.
resultsAfter adjusting for all covariates, a multivariate binary logistic regression analysis revealed that the OBS was negatively correlated with constipation in males [odds ratios (OR) (95% confidence intervals (CI)): 0.937 (0.888, 0.988), P = 0.017], and diarrhea in females [OR (95%CI): 0.951 (0.916, 0.987), P = 0.009]. RCS analysis identified a negative linear trend between OBS and constipation in males (P for non-linearity = 0.63), as well as between OBS and diarrhea in females (P for non-linearity > 0.05).
conclusionThe current study found a negative correlation between the OBS and the risk of constipation in males, along with diarrhea in females. Oxidative stress, gut microbiota, and sex differences may be associated with intestinal dysfunction. These findings suggest that antioxidant-rich dietary modifications may be an effective strategy for preventing constipation in males and diarrhea in females.
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