Evidence map›Paper›PMID 39844257›Full record

ArticleEuropean journal of medical research2025

MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma.

Changsheng Zhou, Jia Liu, Xudong Hu, Lu Lu, Juan Hou, Jian Wang, Liqun Jiang, Shuangshuang Huang, Yu Lin, Luyao Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changsheng Zhou *Departments of Respiratory and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University, Cangnan, Zhejiang, 325800, China.
Jia Liu *Department of Clinical Laboratory, Jingjiang People's Hospital Affiliated With Yangzhou University, Jingjiang, 214500, China.
Xudong Hu *Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Lu LuDepartments of Respiratory and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University, Cangnan, Zhejiang, 325800, China.
Juan HouDepartment of Oncology, Jingjiang People's Hospital Affiliated With Yangzhou University, Jingjiang, 214500, China.
Jian WangDepartments of Respiratory and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University, Cangnan, Zhejiang, 325800, China.
Liqun JiangDepartment of Thoracic Surgery, Jingjiang People's Hospital Affiliated With Yangzhou University, Jingjiang, 214500, China.
Shuangshuang HuangDepartments of Respiratory and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University, Cangnan, Zhejiang, 325800, China.
Yu LinDepartment of Oncology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215001, Jiangsu, China.
Luyao LiuDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Lingling CuiCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China. cll@zzu.edu.cn.
Yiqian LiuDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. liuyiqian@njmu.edu.cn.
Yufeng HuangDepartment of Oncology, Jingjiang People's Hospital Affiliated With Yangzhou University, Jingjiang, 214500, China. one1210@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol metabolism is abnormally active in tumour cells. Metabolic enzymes related to cholesterol metabolism are upregulated in tumours, but their nonmetabolic functions remain unclear. We found that MVK (mevalonate kinase) is upregulated in lung adenocarcinoma tissues vs. normal tissues and that its expression can be induced by constitutively activated Kras. By investigating the molecular mechanisms involved, we discovered that MVK interacts with TBK1, inhibiting TBK1 phosphorylation and thereby suppressing cGAS-Sting signalling. In addition, we found a negative correlation between MVK expression and CD8

Indexed as

Adenocarcinoma of LungLung NeoplasmsMembrane ProteinsNucleotidyltransferasesProto-Oncogene Proteins p21(ras)Cell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGene Expression Regulation, NeoplasticHumansProtein Serine-Threonine KinasesSignal TransductionSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseKRAS protein, humanMembrane ProteinsNucleotidyltransferasesProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)STING1 protein, humanSTING ProteinTBK1 protein, humanCGAS-Sting signallingKrasLung adenocarcinomaMevalonate kinase

Identifiers

PMID39844257
PMCPMC11752689

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.