Evidence map›Paper›PMID 39844285›Full record

SynthesisClinical epigenetics2025

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium.

Irene F Marques, Carola Domènech-Panicello, Madelon L Geurtsen, Thanh T Hoang, Rebecca Richmond, Kristen Polinski, Lea Sirignano, Christian M Page, Anne-Claire Binter, Todd Everson and 14 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Irene F MarquesGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Carola Domènech-PanicelloISGlobal, Barcelona, Spain.
Madelon L GeurtsenGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Thanh T HoangDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Rebecca RichmondMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Kristen PolinskiDivision of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Anne-Claire BinterISGlobal, Barcelona, Spain.
Todd EversonGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Amber BurtGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Michael DeuschleDepartment of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Maria GillesDepartment of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Sunni L MumfordDivision of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Irwin K M ReissDepartment of Neonatal and Pediatric Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Marijn J VermeulenDepartment of Neonatal and Pediatric Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Inês ChavesDepartment of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Edwina YeungDivision of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Mònica GuxensISGlobal, Barcelona, Spain.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. j.felix@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNight shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation.

methodsA total of 4487 mother-newborn pairs from 7 studies were included. Maternal night shift work during pregnancy was ascertained via questionnaires and harmonized into "any" versus "no". DNA methylation was measured in cord blood using the Illumina Infinium Methylation arrays. Robust linear regression models adjusted for relevant confounders were run in the individual cohorts, and results were meta-analyzed.

resultsMaternal night shift work during pregnancy ranged from 3.4% to 26.3%. Three CpGs were differentially methylated in relation to maternal night shift work during pregnancy at a false discovery rate adjusted P < 0.05: cg10945885 (estimate (β) 0.38%, standard error (SE) 0.07), cg00773359 (β 0.25%, SE 0.05), and cg21836426 (β - 0.29%, SE 0.05). Associations of the identified CpGs were found in previous literature for gestational age and childhood and adolescent BMI. In a mouse model of prenatal jet lag exposure, information on offspring DNA methylation of ten homologous genes annotated to the 16 CpGs with P < 1 × 10

conclusionMaternal night shift work during pregnancy was associated with newborn DNA methylation at 3 CpGs. Top findings overlapped with those in a mouse model of gestational jet lag. This work strengthens evidence that DNA methylation could be a marker or mediator of impacts of circadian rhythm disturbances.

Indexed as

DNA MethylationPrenatal Exposure Delayed EffectsShift Work ScheduleWork Schedule ToleranceAdultAnimalsCircadian RhythmCpG IslandsEpigenesis, GeneticFemaleFetal BloodHumansInfant, NewbornMicePregnancyCohort studyDNA methylationEpigeneticsNight shift workPregnancy

Identifiers

PMID39844285
PMCPMC11756212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.