Evidence map›Paper›PMID 39844704›Full record

ArticleSe pu = Chinese journal of chromatography2025

[Analysis of ischemic stroke biomarkers based on non-targeted metabolomics].

Fei Xu, Tian-Ping Liu, Ya-Jin Guan, Wei-Chao Hao, Ding-Sheng Wen, Shui-Lin Xie, Ya-Nan Bie

Abstract readEnglish Abstract
In one paragraph

Article in Se pu = Chinese journal of chromatography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fei XuGuangdong Mingzhu Biotechnology Co., Ltd., Foshan 528500, China.
Tian-Ping LiuGuangdong Mingzhu Biotechnology Co., Ltd., Foshan 528500, China.
Ya-Jin GuanGuangdong Mingzhu Biotechnology Co., Ltd., Foshan 528500, China.
Wei-Chao HaoDepartment of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510062, China.
Ding-Sheng WenCollege of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Shui-Lin XieSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Ya-Nan BieSchool of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers for ischemic stroke (IS) are yet to fulfill clinical requirements. This study used non-targeted metabolomics to investigate differential metabolites and metabolic pathways in plasma and brain tissue following IS, with the aim of identifying new potential biomarkers and therapeutic targets. Twelve Tibetan miniature pigs were randomly assigned to a model- or sham-operation group. An electrocoagulation-based anterior temporal approach was employed to occlude the middle cerebral artery, thereby creating a model for IS. Plasma and brain tissue samples were collected 36 h post-surgery and analyzed using liquid chromatography-mass spectrometry. Principal component and partial least squares discriminant analyses were used to screen for differential metabolites and exclude exogenous metabolites at

Indexed as

BiomarkersIschemic StrokeMetabolomicsAnimalsBrainChromatography, LiquidMetabolomeSwineSwine, MiniatureBiomarkersbiomarkersbrain tissueischemic stroke (IS)non-target metabolomicsplasma

Identifiers

PMID39844704
PMCPMC11758226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.