Evidence map›Paper›PMID 39845330›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025

Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.

Juan Tan, Lin Wang, Hong Li, Honggang Wang, Xiaozhong Yang

Abstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juan Tan *Department of General Practice, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Lin Wang *Department of General Practice, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Hong LiDepartment of Health Management Center, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Honggang WangDepartment of Gastroenterology, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Xiaozhong YangDepartment of Gastroenterology, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the relationship between serum uric acid (SUA) levels and femoral neck bone mineral density (BMD) in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Patients and Methods: This cross-sectional study included 597 adult inpatients with type 2 diabetes mellitus and ultrasonography-confirmed fatty liver disease. Participants were stratified into tertiles based on femoral neck BMD. Gender-stratified linear regression analyses were performed to assess the relationship between SUA and femoral neck BMD. Nonlinear associations were explored using generalized additive models and two-piece linear regression. Results: No significant linear association was observed between SUA and femoral neck BMD in either gender (all Conclusion: In male MAFLD patients, SUA levels exhibit a nonlinear relationship with femoral neck BMD, with a positive association observed between 300 μmol/L and 388 μmol/L. This relationship was not observed in female patients, suggesting gender-specific effects of SUA on bone health in MAFLD.

Indexed as

bone mineral densitymetabolic dysfunction-associated fatty liver diseaseserum uric acidtype 2 diabetes

Identifiers

PMID39845330
PMCPMC11750728

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.