ArticleBrain communications2025
Non-motor asymmetry and dopamine degeneration in Parkinson's disease.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Clinical Validation of Pupil Response During Walking in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Differences in Spatial Cognition and Motor-Cognitive Integration by Side of Onset in People with Parkinson's Disease.Brain sciences · 2026Article
- Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson's Disease: An ExploratoryJournal of clinical medicine · 2026Article
- Is motor asymmetry a predictor of non-motor outcomes in Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease.npj women's health · 2026Article
- Impact of motor symptom asymmetry on non-motor outcomes in Parkinson's disease: a systematic review.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asymmetric dopaminergic degeneration of the striatum is a characteristic feature of Parkinson's disease, associated with right-left asymmetry in motor function. As such, studying asymmetry provides insights into progressive neurodegeneration between cerebral hemispheres. Given the impact of Lewy pathology on various neurotransmitter systems beyond the dopaminergic, it may be that other neuronal systems in the predominantly affected hemisphere are similarly affected. According to this hypothesis, asymmetry in dopaminergic degeneration would be expected to coincide with asymmetry in other neurotransmitter systems. Consequently, asymmetry in functions primarily dependent on dopaminergic integrity, such as motor function, should correlate with asymmetry in bilateral non-motor functions that rely on other cerebral systems, such as pupillary function. Therefore, this study tested whether right-left asymmetry in bilateral non-motor measures correlates with asymmetry in dopaminergic striatal integrity. We also tested whether asymmetric striatal degeneration is associated with greater asymmetry in non-motor measures overall. Using a comparative cross-sectional design, we recruited newly diagnosed patients with Parkinson's disease with predominantly right-sided (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.