Evidence map›Paper›PMID 39846187›Full record

ArticleZoological research2025

Ribosome profiling and single-cell RNA sequencing identify the unfolded protein response as a key regulator of pigeon lactation.

Jing Liu, San-Feng Liu, Hui-Rong Mao, Hong-Xia Jiang, Shui-Bing Liu, Xiao-Fei Xu, Jin-Tao Wu, Xun Liu, Wen-Tao Zhang, Xiao-Long Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing LiuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
San-Feng LiuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Hui-Rong MaoCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Hong-Xia JiangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Shui-Bing LiuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Xiao-Fei XuZhongshan Shiqi Pigeon Breeding Limited Company, Zhongshan, Guangdong 528400, China.
Jin-Tao WuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Xun LiuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Wen-Tao ZhangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Xiao-Long HuCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
Biao ChenNational Key Laboratory for Swine Genetic Improvement and Germplasm Innovation, Ministry of Science and Technology of China, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pigeons and certain other avian species produce a milk-like secretion in their crop sacs to nourish offspring, yet the detailed processes involved are not fully elucidated. This study investigated the crop sacs of 225-day-old unpaired non-lactating male pigeons (MN) and males initiating lactation on the first day after incubation (ML). Using RNA sequencing, ribosome profiling, and single-cell transcriptome sequencing (scRNA-seq), we identified a significant up-regulation of genes associated with ribosome assembly and protein synthesis in ML compared to MN. Results from scRNA-seq analysis identified 12 distinct cell types and 22 clusters, with secretory epithelial cells (SECs) exhibiting marked expression of plasma cell markers, including

Indexed as

ColumbidaeLactationRibosomesUnfolded Protein ResponseAnimalsFemaleGene Expression RegulationMaleRibosome ProfilingSequence Analysis, RNASingle-Cell AnalysisCrop lactationPigeonRibosome profilingSecretory epithelial cellsSignaling pathwaySingle-cell RNA sequencing

Identifiers

PMID39846187
PMCPMC11890991

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.