Evidence map›Paper›PMID 39846248›Full record

ArticleCancer biology & therapy2025

miR-301a-mediated crosstalk between the Hedgehog and HIPPO/YAP signaling pathways promotes pancreatic cancer.

Bing Qi, Yuqiong Wang, Xian Zhu, Yanfang Gong, Jing Jin, Hongyu Wu, Xiaohua Man, Feng Liu, Wenzhu Yao, Jun Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Hippo/YAP signaling's multifaceted crosstalk in cancer.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bing QiInstitute of Oncology, Second Affiliated Hospital, Xi'an Medical University, Xi'an, China.ORCID 0000-0001-8025-493X
Yuqiong WangDepartment of Gastroenterology, The Hospital of 92608 People's Liberation Army of China (PLA) Troops, Shanghai, China.
Xian ZhuDepartment of Gastroenterology, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Yanfang GongDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Jing JinDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Hongyu WuDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xiaohua ManDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Feng LiuDepartment of Gastroenterology, Tongchuan People's Hospital, Tongchuan, China.
Wenzhu YaoInstitute of Oncology, Second Affiliated Hospital, Xi'an Medical University, Xi'an, China.
Jun GaoInstitute of Oncology, Second Affiliated Hospital, Xi'an Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge in oncology due to its dismal prognosis and limited therapeutic options. In this study, we investigated the role of miR-301a in facilitating crosstalk between the Hedgehog (Hh) and HIPPO/YAP signaling pathways during the progression of PDAC. Our findings revealed that miR-301a served as a central regulatory node, targeting Gli1 within the Hh pathway and STK4 within the HIPPO/YAP pathway. Immunohistochemical and molecular analyses confirmed dysregulation of pathway components in pancreatic cancer, underscoring the pivotal role of miR-301a. Functional assays demonstrated the impact of miR-301a on cell proliferation and apoptosis, particularly in synergy with TNF-α. Overall, our study elucidated the intricate interplay between the Hh and HIPPO/YAP pathways mediated by miR-301a, providing valuable insights into potential therapeutic strategies for intervening in PDAC.

Indexed as

Adaptor Proteins, Signal TransducingCarcinoma, Pancreatic DuctalHedgehog ProteinsMicroRNAsPancreatic NeoplasmsPhosphoproteinsProtein Serine-Threonine KinasesTranscription FactorsAnimalsApoptosisCell Cycle ProteinsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHippo KinasesHippo Signaling PathwayAdaptor Proteins, Signal TransducingCell Cycle ProteinsGLI1 protein, humanHedgehog ProteinsHippo KinasesIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN301A microRNA, humanPhosphoproteinsProtein Serine-Threonine KinasesSTK4 protein, humanTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsZinc Finger Protein GLI1Gli1HedgehogHippo/YAPmiR-301aMST1(STK4)

Identifiers

PMID39846248
PMCPMC11760222

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.