Evidence map›Paper›PMID 39847134›Full record

ArticleCalcified tissue international2025

The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.

William Querido, No'ad Shanas, Adaeze P Radway, Brandon C Jones, Mikayel Ispiryan, Huaqing Zhao, Michael W Hast, Chamith S Rajapakse, Nancy Pleshko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William QueridoDepartment of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.ORCID http://orcid.org/0000-0002-1484-2415
No'ad ShanasDepartment of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.
Adaeze P RadwayDepartment of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.
Brandon C JonesDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Mikayel IspiryanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Huaqing ZhaoDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Michael W HastDepartment of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Chamith S RajapakseDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Nancy PleshkoDepartment of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA. npleshko@temple.edu.

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Non-Invasive Determination of Bone Quality Markers by Monte Carlo Modeling and Optical SpectroscopyR21AR080517 · NIAMS · TEMPLE UNIV OF THE COMMONWEALTH · PI PATIL, CHETAN A, PLESHKO, NANCY · 2022 to 2023
$377k
Non-Destructive Spectroscopic Assessment of Bone Water at Microscopic ResolutionR21AR071704 · NIAMS · TEMPLE UNIV OF THE COMMONWEALTH · PI PLESHKO, NANCY · 2017 to 2018
$376k
National Institutes of Health (NIH) P30AR069619National Institutes of Health (NIH) R21AR071704NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R21 AR071704NIAMS NIH HHS R21 AR080517
6 · The paper itself

Abstract

Bone mechanical function is determined by multiple factors, some of which are still being elucidated. Here, we present a multivariate analysis of the role of bone tissue composition in the proximal femur stiffness of cadaver bones (n = 12, age 44-93). Stiffness was assessed by testing under loading conditions simulating a sideways fall onto the hip. Compositional properties of cortical and trabecular tissues were quantified in femoral neck cross sections by Fourier transform infrared (FTIR) spectroscopy and near infrared (NIR) spectroscopy. In addition, cross-sectional areas and cortical thickness and tissue mineral density (TMD) were measured at the femoral neck. Pearson correlation analysis showed a significant (p < 0.05) negative relationship between bone stiffness and cortical and trabecular water content, both total (r = -0.63) and tightly bound to matrix and mineral (r = -55). Additionally, significant (p < 0.05) positive correlations were found between stiffness and bone area, both total (r = 0.67) and trabecular (r = 0.58). However, linear regression using each of these properties to predict bone stiffness resulted in weak models (R

Indexed as

Bone and BonesFemurFemur NeckWaterAdultAgedAged, 80 and overBiomechanical PhenomenaBone DensityFemaleHumansMaleMiddle AgedSpectroscopy, Fourier Transform InfraredSpectroscopy, Near-InfraredWaterBone stiffnessBone tissue waterInfrared spectroscopyMultivariate analysisProximal femur mechanics

Identifiers

PMID39847134
PMCPMC11759464

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.